不同频率电针对抑郁症模型大鼠行为学和β-内啡肽的差异性研究.docVIP

  不同频率电针对抑郁症模型大鼠行为学和 β-内啡肽的差异性研究# 王欣君，王玲玲** 5 10 15 （南京中医药大学第二临床医学院，南京 210038） 摘要：[目的]观察不同频率电针对抑郁症模型大鼠行为学和β-内啡肽的差异。[方法]制作慢 性应激型抑郁症模型大鼠，分别予以氟西汀、假针、2HZ 电针、100HZ 电针治疗 7 天，测 定行为学表现和β-内啡肽水平。[结果] 2Hz 电针组和 100Hz 电针组与模型组、假针组、氟 西汀组比较，糖水消耗量和水平运动、垂直运动都有差异（P＜0.05），而氟西汀组与模型 组、假针组并无差异。2HZ 电针组和 100HZ 电针组比较，糖水消耗量和水平运动无差异， 但垂直运动有差异（P＜0.05）。2Hz 电针和 100Hz 电针脑内β-内啡肽（β-EP）水平均降 低（P＜0.05），2Hz 电针降低显著（P＜0.05）。2Hz 电针和 100Hz 电针β-EP 水平均与糖 水消耗量和水平运动有相关性，但 2Hz 电针组在纹状体表现出相关性，100Hz 电针组在中 缝核表现出相关性。[结论] 2Hz 电针和 100Hz 电针对抑郁症模型大鼠均表现出抗抑郁快速 起效特点，2Hz 电针效果优于 100Hz 电针，该效应特点与β-EP 水平降低有关。2 种频率电 针β-EP 水平与行为学的相关性表现在脑的不同部位。β-EP 的受体—μ-受体及其信号通 路的研究将是进一步深入研究的目标。 关键词：针灸；抑郁症；频率；β-内啡肽 中图分类号：R395.5 20 The Different Influence on Behavioral Performance and beta-endorphin Levels of Depression Model Rats Treated with Different Frequencies of Electro-acupuncture WANG Xinjun, WANG Lingling 25 30 35 40 (2nd Clinic Medicine School, Nanjing University of TCM, NanJing 210038) Abstract: [Objective]To observe the behavioral performance and beta-endorphin levels of depression model rats treated with different frequencies of electro-acupuncture.[Methods] we made the chronic stress-induced depression model rats, which were treated with fluoxetine, sham acupuncture, 2HZ EA and 100HZ EA for seven days respectively; and measured the behavioral performance and beta-endorphin levels of rats. [Results] 2Hz EA group and 100Hz EA group both increased in sugar consumption, horizontal movement and vertical movement comparing with the model group, sham acupuncture group, the fluoxetine group respectively (P0.05), while there was no difference among fluoxetine group, model group and sham acupuncture group. 2HZ EA group corresponds to 100HZ EA group in sugar consumption and horizontal movement, but 2HZ EA had an advantage in vertical motion (P0.05).β-endorphin (beta-EP) decreased in 2Hz EA group and 100Hz EA group (P0.05), and significantly in 2Hz EA group (P 0.05). 2Hz EA and 100Hz EA were both related to beta-EP level, sugar consumptio