槲皮素对肥胖大鼠及其后代血压影响的研究.docVIP

  槲皮素对肥胖大鼠及其后代血压影响的 研究# 赵佳夕，赵洁，董文红，徐琳琳，桑田，许雅君** 5 10 15 20 25 30 35 40 （北京大学公共卫生学院营养与食品卫生学系，北京 100013） 摘要：目的：研究孕期给予槲皮素对肥胖母鼠及其后代血压的影响。方法：建立营养性肥胖 雌性 SD 大鼠模型，交配受孕，随机分成 5 组，每组 16 只孕鼠，整个实验期进食高脂饲料， 并分别以 0、50、100、200mg/kg 剂量的槲皮素灌胃；以 16 只正常体质量孕鼠做为空白对照， 整个实验期喂食基础饲料并以溶剂灌胃。记录母鼠孕 6 天（d）、13d、20d 血压，及仔鼠生 后 56d、98d 血压。结果：各组母鼠的血压于整个孕期的差异均无统计学意义。高脂对照组 后代血压显著高于空白对照组，随槲皮素干预剂量增大，仔鼠收缩压（SBP）逐渐降低，舒 张压（DBP）未见明显改变。槲皮素的该作用在 98d 喂食高脂饲料的仔鼠中消失。结论：孕 期给予肥胖母鼠一定剂量槲皮素干预，可有效降低新生仔鼠 SBP，但对于喂食高脂饲料的成 年（98d）仔鼠该作用消失。肥胖母鼠孕期未见槲皮素的降压作用。 关键词：肥胖；高血压；槲皮素；降压 中图分类号：R153.1 Effect of quercetin on blood pressure of obese rats offspring ZHAO Jiaxi, ZHAO Jie, DONG Wenhong, XU Linlin, SANG Tian, XU Yajun (Department of Nutrition and Food Hygiene, School of Public Health, Peking University, Beijing 100013) Abstract: [Purpose] To study the effect of quercetin given during pregnancy period of obese rats on blood pressure of the offspring. [Methods] The nutritional obese rats were mated, and pregnant rats were randomly divided into 5 groups, 16 rats in each. Fed high fat diet during pregnancy and lactation, obese pregnant rats were respectively irrigated 0mg/kgmb, 50mg/kgmb, 100mg/kgmb, 200mg/kgmb quercetin throughout pregnancy. The blood pressure of maternal rat was recorded on 6d, 13, 20d during the pregnancy, and blood pressure of offspring was recorded on 56d, 98d (after birth). [Result] The blood pressure of all groups of maternal rats was at the same level. High fat diet group’s blood pressure of offspring was significantly higher than control group. With the dose of quercetin increased, offspring’s systolic blood pressure (SBP) decreased, diastolic blood pressure (DBP) did not change significantly. This effect of quercetin disappeared on 98d in pups fed on high fat diet. [Conclusion] Giving a dose of quercetin to obese female rats during pregnancy can effectively reduce the newborn offspring’s SBP. However, this effect disappeared on 98d in pups fed on high-fat diet. There is no effect of quercetin on blood pres