维生素E自微乳化载药体系制备及其性质研究.docVIP

  维生素 E 自微乳化载药体系制备及其性质 研究# 王海洋，钟芳，李玥，易江** 5 10 15 20 25 30 35 40 （江南大学食品学院，江苏 无锡 214122） 摘要：本文比较了 Tween 系列、Cremophor EL 和 Cremophor RH 4 等表面活性剂形成维生素 E 自微乳化载药体系（VE-SMEEDS）的微乳相图。研究了 Km 值(表面活性剂/助表面活性剂的 质量比）对微乳相图的影响。考察了助表面活性剂和表面活性剂对微乳粒径的影响。采用电 导率法对 VE-SMEEDS 稀释过程进行了相区划分。考察了温度、氯化钠和蔗糖浓度对 VE-SMEEDS 微乳稳定性的影响。结果表明，最佳 VE-SMEEDS 配方是以 Cremophor RH 40 为表面活性剂， 乙醇为助表面活性剂，Km=3,其中 Cremophor RH 40 和维生素 E 的质量比 4：3，VE 载量为 36%。其 O/W 型微乳的平均粒径为 46.32±1.77nm 且对温度、NaCl 和蔗糖稳定。 关键词：食品加工与配料；自微乳化载药体系；维生素 E；粒径 中图分类号：R943.3 Preparation and Characterization of vitamin E SMEDDS WANG Haiyang, ZHONG Fang, LI Yue, YI Jiang (School of Food Sicence and Technology, Jiangnan University, Wuxi Jiangsu 214122) Abstract: This study investigated the pseudoternary phase diagrams of VE self-microemulsifying drug delivery systems(VE-SMEDDS) formed by using different surfactants including Tween series, Cremophor EL and Cremophor RH 40. The effects of different Km on the pseudoternary phase diagrams of VE-SMEEDS as well as the influences of surfactant and co-surfactant on particle size of O/W microemulsion were studied. The phase transition of VE-SMEEDS in the dilution progress was determined by conductance measurement. The stability of VE-SMEEDS as functions of temperature, NaCl and sucrose concentration was also investigated. The results showed that the optimal VE-SMEEDS formulation was obtained when Cremophor RH 40 and ethanol were used as surfactant and co-surfactant respectively (Km=3). The mass ratio of Cremophor RH 40 and VE was 4:3 and the content of VE in the system was 36% (w/w). The average particle size of O/W microemulsion was 46.32 ± 1.77nm. The VE-SMEEDS exhibited good stability on temperature, NaCl and sucrose solution. Key words: Functional Food Ingredients;SMEEDS; vitamin E; particle size; pseudoternary phase diagram 0 引言 自微乳化药物传递体系（self-microemulsifying drug delivery systems, SMEDDS）通常是 由表面活性剂、油相、油溶性药物和（或）助表面活性剂组成的药物传递体系。该体系最大 的特点是在加水稀释搅拌的情况下可自发乳化形成 O/W 型微乳[1]。SMEDDS 对脂溶性药物 或营养素起到增溶和保护作用，并可以