口腔粘膜异常增生上皮和鳞癌组织凋亡相关蛋白的表达研究.pdfVIP

口腔粘膜异常增生上皮和鳞癌组织凋亡相关蛋白的表达研究.pdf

  1. 1、原创力文档(book118)网站文档一经付费(服务费),不意味着购买了该文档的版权,仅供个人/单位学习、研究之用,不得用于商业用途,未经授权,严禁复制、发行、汇编、翻译或者网络传播等,侵权必究。。
  2. 2、本站所有内容均由合作方或网友上传,本站不对文档的完整性、权威性及其观点立场正确性做任何保证或承诺!文档内容仅供研究参考,付费前请自行鉴别。如您付费,意味着您自己接受本站规则且自行承担风险,本站不退款、不进行额外附加服务;查看《如何避免下载的几个坑》。如果您已付费下载过本站文档,您可以点击 这里二次下载
  3. 3、如文档侵犯商业秘密、侵犯著作权、侵犯人身权等,请点击“版权申诉”(推荐),也可以打举报电话:400-050-0827(电话支持时间:9:00-18:30)。
  4. 4、该文档为VIP文档,如果想要下载,成为VIP会员后,下载免费。
  5. 5、成为VIP后,下载本文档将扣除1次下载权益。下载后,不支持退款、换文档。如有疑问请联系我们
  6. 6、成为VIP后,您将拥有八大权益,权益包括:VIP文档下载权益、阅读免打扰、文档格式转换、高级专利检索、专属身份标志、高级客服、多端互通、版权登记。
  7. 7、VIP文档为合作方或网友上传,每下载1次, 网站将根据用户上传文档的质量评分、类型等,对文档贡献者给予高额补贴、流量扶持。如果你也想贡献VIP文档。上传文档
查看更多
2002 1 37 1 Chin J S oma ol, January 2002, Vol 37, No. 1 65 关为群 于世凤 高岩 ! p53Bcl2 Bax SP 10 , 48 42 p53Bcl2 Bax p53Bcl2Bax 0% , 20% 60 % ; , , p53 ( P 005) , Bcl2 ( P 005) , Bax ( P 005) , ; p53 , Bcl2 , Bax , p53 Bax , p53 Bcl2 , p53 , p53 Bcl2 , Bax , , , , ! , ; , ; Expression of apoptosisrelated protein in epithelial dysplasia and squamous cell carcinoma GUAN * * Weiqun , YU Shfieng , GAO Yan. Dep artment of Stomatology, Union Hospital, ujian Medical University, uzhou350001, China Abstract! Objective To s udy he expression and signif icance of apop osisrela ed pro ein p53, Bcl2, and Bax during he developmen of oral squamous cell carcinoma ( SCC) . Methods The expression w as observed in 10 normal oral epi helia, 48 dysplasia epi helia and 42 SCC by immunohis ochemical evalua ion. Results In normal mucosa, he posi ive ra e of p53, Bcl2 and Bax were 0% , 20% and 60% . In dysplasia epi helia, he posi ive ra e of p53 is increased ( P 005) , he posi ive ra e of Bcl2 and Bax remained no signif ican change ( P 005) , bu he posi ive in ensi y in severe dysplasia was higher han in mild group . In SCC, he posi ive ra e of Bcl2 increased signif ican ly ( compared w i h dysplasia, P 005) , while he expression of Bax w as decreased w i h he increase of SCC his ological grade. Fur her analysis show ed he correla ion w as eviden in p53 and Bax in dysplasia, and in p53 and Bcl2 in SCC. Conclusions In dysplasia, p53 gene mu a ion resul s in accumula ion of dysplasia cells . In SCC, he coopera ion of p53, Bcl2 and Bax resul s in he progression of SCC. Apop osis genes could work ei her independen ely or coopera ely. Key words! Carcinoma, squamous cell ; Leukoplakia, oral; Immunohis ochemis ry

文档评论(0)

ww88606 + 关注
实名认证
文档贡献者

该用户很懒,什么也没介绍

1亿VIP精品文档

相关文档