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2002 1 37 1 Chin J S oma ol, January 2002, Vol 37, No. 1 65
关为群 于世凤 高岩
! p53Bcl2 Bax
SP 10 , 48 42
p53Bcl2 Bax p53Bcl2Bax 0% , 20%
60 % ; , , p53 ( P 005) , Bcl2 ( P
005) , Bax ( P 005) , ; p53
, Bcl2 , Bax , p53
Bax , p53 Bcl2 , p53
, p53 Bcl2 , Bax ,
, , ,
! , ; , ;
Expression of apoptosisrelated protein in epithelial dysplasia and squamous cell carcinoma GUAN
* *
Weiqun , YU Shfieng , GAO Yan. Dep artment of Stomatology, Union Hospital, ujian Medical University,
uzhou350001, China
Abstract! Objective To s udy he expression and signif icance of apop osisrela ed pro ein p53, Bcl2,
and Bax during he developmen of oral squamous cell carcinoma ( SCC) . Methods The expression w as observed
in 10 normal oral epi helia, 48 dysplasia epi helia and 42 SCC by immunohis ochemical evalua ion. Results In
normal mucosa, he posi ive ra e of p53, Bcl2 and Bax were 0% , 20% and 60% . In dysplasia epi helia, he
posi ive ra e of p53 is increased ( P 005) , he posi ive ra e of Bcl2 and Bax remained no signif ican change
( P 005) , bu he posi ive in ensi y in severe dysplasia was higher han in mild group . In SCC, he posi ive ra e
of Bcl2 increased signif ican ly ( compared w i h dysplasia, P 005) , while he expression of Bax w as decreased
w i h he increase of SCC his ological grade. Fur her analysis show ed he correla ion w as eviden in p53 and Bax in
dysplasia, and in p53 and Bcl2 in SCC. Conclusions In dysplasia, p53 gene mu a ion resul s in accumula ion of
dysplasia cells . In SCC, he coopera ion of p53, Bcl2 and Bax resul s in he progression of SCC. Apop osis genes
could work ei her independen ely or coopera ely.
Key words! Carcinoma, squamous cell ; Leukoplakia, oral; Immunohis ochemis ry
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