三苯基锡壳聚糖磷酸酯的合成、表征及其杀钉螺活性.pdfVIP

《化学通报》在线预览版 三苯基锡壳聚糖磷酸酯的合成、表征及其杀钉螺活性 1 1,2* 2 3 1 曹佐英 许海峰 唐瑞仁 魏望远 许外 1 2 3 （湖南理工学院化学化工系 岳阳 414000 ; 中南大学化学化工学院 长沙 410083;湖南省血吸虫病防治所 岳阳 414000 ） 摘 要 用磷酸二氢钠和尿素在稀醋酸介质中对壳聚糖（CTS ）进行磷酸化改性，得到壳聚糖磷酸酯(P-CTS)，然后 在85%的甲醇中与三苯基氯化锡发生亲核取代反应，合成出三苯基锡壳聚糖磷酸酯(P-CTS-SnPh3)，通过红外光谱、核磁 共振、热分析和粉末X-射线衍射等手段表征了这些化合物。用所得产品进行杀钉螺活性试验，结果显示，当其浓度在0.5 mg/L 以上时，浸杀3天后，钉螺的死亡率达100%。 关键词 三苯基锡壳聚糖磷酸酯 合成 表征 杀钉螺活性 Synthesis, Characterization and Molluscicidal Activity of Triphenyltin Phosphorylated Chitosan Cao Zuoying1 Xu Haifeng1,2* Tang Ruiren2 Wei Wangyuan3 Xu Wai1 1 （Department of Chemistry and Chemical Engineering, Hunan Institute of Science and Technology , Yueyang 414000; 2School of Chemistry and Chemical Engineering, Central South University, Changsha 410083; 3Hunan Institute of Parasitic Diseases, Yueyang 414000) Abstract Phosphorylated chitosan (phosphorylate-modified chitosan, P-CTS) was synthesized by the reaction of monosodium orthophosphate with urea in the presence of HAc. Triphenyltin phosphorylated chitosan (P-CTS-SnPh3) was further prepared by the nucleophilic substitution reaction of P-CTS with triphenyltin chloride in the presence of 85% CH3OH. The compounds were characterized and analyzed by IR, NMR, TG-DTA and X-ray diffraction etc. The results of the tests of molluscicidal activity showed that the oncomelania death rate is 100% at the concentration of P-CTS-SnPh3 over 0.5mg/L and the soaking time is 3d. Keywords Triphenyltin phosphorylated chitosan, Synthesis, Characterization, Molluscicidal activity