手骨密度对类风湿关节炎早期诊断意义及关节侵蚀的预测.pdfVIP

rheumatoidarthritisRA RA 1RA 14 bone mineral density, BMDX (rheumatoid factorRF)C C reactive proteinCRPerythrocyte sedimentation rate ESR2RA T 32 BMD RFX RA OR 42 RA Larsen group1group2BMDRFESR CRP 12BMD RA 61.5 80.7 X RFBMD RA 3BMDRFCRP HAQ P 0.054RA BMD OR 8.33CRP RF ESR 5RA CRP (1) RA (2) RA X (3) RA RA X 1 ABSTRACT Objective: We explored the diagnostic significance of hand bone mineral density and the role it plays in the articular erosion in patients with rheumatoid arthritis ( RA ) . Furthermore ,we evaluate several risk factors comprehensively combining with other laboratory and clinical markers . Method: (1) 46 patients with RA and population controls (n = 144) randomly selected after matching for age, sex, and weight were studied. Bone mineral density (BMD) were measured in hand,Lumbar spine.femur by dual energy x ray absorptiometry from RA patients and controls, and X ray of hand ,rheumatoid factor RFC reactive protein CRPerythrocyte sedimentation rate ESRwere measured at the same time.(2) BMD of RA patients and controls were played in Tow-Sample T test.(3) Diagnosing 2 year and controls were measured hand BMD, hand X ration , RF. We investigated the distribution of hand BMD, hand X ray , RF in patients of the two groups . A univariate analysis was used to determine whether hand BMD, hand X ray , RF plays a role on diagnose in RA . (4) Diagnosing 2 year and controls were measured hand BMD, RF, CRP, ESR, to determine which had the best predictive value for severe radiographic damage . Results: (1)Changes