CEA、CA125、NSE、SCC联合检测在肺癌诊断中的价值.pdfVIP

· 2380 · M0DERN ONC0IOGY．Dec．2010．VOI．18．N0．12 CEA、CA125、NSE、SCC联合检测在肺癌诊断中的价值 赵 田，陈晓华，傅冬梅 ，孙月庭 DiagnositcvalueofcombineddetectionofCEA，CA125，NSEasndSCCinlungcancer ZHAO Tian，CHEN Xiao—hua，FU Dong—mei，SUN Yue—ring DepartmentofClinicalLaboratory，ChinesePeoplesLiberationArmy161stHospital，Wuhan430010，China． A【bstract】 Objective：Toexplorethediagnosticvalueofcombineddetectionoffourtumormarkers，CEA，CA125， NSE，SCCinthedeterminationoflungcancer．Methods：UsingMEIA andenzyme—linked immunosorbentassay (ELISA)，seurmCEA，CA125，NSE，SCCweredetemrinedin96lungcancerpatientsand30benignlungdiseasepa— tientsand30healthypersons．Results：Serum concentrationsofCEA，CA125，NSE，SCCweresignificantlyhigherin patientswithlungcancerthanpatientswithbening lungdiseasepatientsandhealthypersons(P0．O1)．Thelevels offourtumormarkers wereassociatedwithpathologytypeoflungcancer．Thesingletestsensitivityoffourtumor mrakersfordiangosisoflungcancerwere48．9％ ，51．O％ ，39．6％ ，18．8％ respectively．Th ecombinedtestsensitivity was92．7％．Theserumlevelsofmakersinpatientswithadvanceddisease(stagellIand1V、weresingificantlyhigher thaninthosewithstageIand Ⅱ．Conclusion：TheassayofCEA，CA125，NSE，SCCinseurm canhelpdifferentia— ringvariousbiologicaltypeoflungcancerandincreasethesensitivity． K【eywords】lungcarcinoma；CEA；CA125；NSE；SCC；diagnosis Modem Oncoloyg2010，18(12)：2380—2382 摘【要】 目的：探讨 CEA、CA125、NSE、SCC联合检测在肺癌诊断中的价值。方法：采用微粒子酶免疫分析和 ELISA方法对96例肺癌、30例肺 良性病患者以及 30例健康体检者进行血清CEA、CA125、NSE、SCC四种肿瘤 标志物检测。结果：肺癌患者血清CEA、CA125、NSE、SCC测定结果显著高于肺良性病患者及健康对照组 (P 0．01)，其测定水平与病理类型有关。四种肿瘤标志物单项检测的阳性率分别为48．9％、51．O％、39．6％、 18．8％，联合检测阳性率提高到92．7％ 。CEA和CA125在TNM临床分期越晚，检测水平越高。结论：CEA、 CA125、NSE、SCC对不同组织类型的肺癌鉴别有一定临床价值 ，而且具有互补性，联合检测可提高阳性诊断 率。 【关键词】肺癌；CEA；CA125；NSE；SCC；诊断 【中图分类号】R734．2