高压氧对脑梗死患者血浆SOD和CRP的影响及临床意义.pdfVIP

2010年 12月第 4卷第 12期 ChinaClinPraeMed。Dec2010，Vo1．4，No．12 · 45 · 高压氧对脑梗死患者血浆 SOD和 CRP的 影响及临床意义 聂艳玲 【摘要】 目的 研究高压氧对脑梗死患者血浆 SOD和CRP的影响及其临床意义。方法 78例脑 梗死患者随机分为高压氧治疗组 (HBO组，4O例)和临床治疗组 (临床组，38例)。临床组给予常规治 疗；HBO组给予高压氧及临床常规治疗；21例健康志愿者为健康对照组 (对照组)。于治疗前、后检测血 清 SOD、CRP含量，同时评价两组的治疗效果。结果 HBO组与临床组治疗前的血清 SOD、含量与健康 组比较，差异有统计学意义 (P0．01)；HBO组治疗后与治疗前比较 ，血清 SOD含量升高及 CRP含量下 降，差异有统计学意义(P0．O1)；HBO组治疗后血清SOD含量升高、CRP含量降低以及总有效率均较 临床组明显 (P0．O1)。结论 高压氧治疗可使脑梗死患者血清SOD活性升高，血清CRP水平降低，机 体清除自由基的能力增强，从而对脑梗死具有 良好疗效。同时提示 SOD、CRP的血清含量可用以判断高 压氧治疗对脑梗死患者的疗效和预后。 【关键词】 高压氧；脑梗死 ；超氧化物歧化酶；C反应蛋白 Studyoftheeffectofhyperbaricoxygenationonactivitiesofserum SOD andCRP anditsclinicalsignifi· canceinpatients、】Irithcerebralinfarction N1EYan—ling．DepartmentofHyperbaricOxygenation．The t People’SHospitalofShangqiu，Henan476100，China 【Abstract】 Objective Tostudytheeffectofhyperbaricoxygenation(HBO)therapyontheactivitiesof serum SOD andCRPofpatientswithcerebralinfarction anditsclinicalsignificance．Methods 78patients withcerebralinfarctionwererandomlydividedintohyperbaricoxygengroup(HBOGroup，40cases)andclinical group(38cases)．Theclinicalgroupwastreatedwithclinicalconventionaltreatmentonly．HBOrgoupwastrea— tedwithHBO combined with clinicalconventionaltreatment．21healthyvolunteerswereassigned tocontrol rgoup．Beforeandaftertreatment，theactivitiesofserum SOD andCRP levelweremeasured，andthecurative effectwereevaluated．Results Thepretreatmentserum SOD andCRP oftheHBO rgoupand clinical group weresignificantlydifferentfromthecontrolgroup(P0．01)．Comparedwiththepretreatmentandposttreat— mentse131mleveloftheHBOgroup，SODraised，CRPlowered，thedifferencewassignificant(P0．O1)． Comparedwithclinicalgroup，SODraised，CRPloweredandthetotalcurerateoftheHBOgroupweremoresig— nificantdifferent(P0．01)．Conclusion HBOtherapyraisedtheactivitiesofSODandlowerhtelevelof CRPinseurm ofthepatientswiht cerebral infarction，andimprovedthefreeradicalsscavengingability inthe body．Th er