Raf激酶抑制蛋白在常见消化系统恶性肿瘤中研究进展.pdfVIP

378 　　肿瘤2013 年4 月第33 卷第4 期　TUM OR Vol. 33, April 2013 DOI: 10.3781/j .issn.1000-7431.2013.04.015 Copyright© 2013 by TUM OR Review 综述 · Raf激酶抑制蛋白在常见消化系统恶性肿瘤中的研究进展 喻　敏，吕农华 南昌大学第一附属医院消化内科　江西南昌　330006 [摘要]　Raf 激酶抑制蛋白 （Raf kinase inhibitory protein，RKIP ）是磷脂酰乙醇胺结合蛋白 （phosphatidylethanolamine- binding protein ，PEBP ）家族的成员之�，其在丝裂原活化蛋白激酶 （mitogen-activated protein kinases ，MAPK ）、 G 蛋 白偶联受体 （G protein-coupled-receptors ，GRCP ）及核因子 -κB （nuclear factor-kappaB ，NF-κB ）等蛋 白 激酶信号转导�路中起着重要的调节作用。近年来，在前列腺癌、乳腺癌及黑素瘤等多种恶性肿瘤中均发现 RKIP 表达下调或缺失，并可能�过抑制��侵袭和肿瘤新生血管形成等方式抑制肿瘤转移。�时有多项研究证实， RKIP 作为�个肿瘤转移抑制基因，参与抑制了多种消化系统恶性肿瘤的转移，使其成为消化系统肿瘤防治研究的 �个新靶点。本文就 RKIP 在常见消化系统恶性肿瘤中的研究进展作�综述。 [关键词]　消化系统肿瘤；MAP 激酶信号系统；Raf 激酶类；磷脂酰乙醇胺结合蛋白质 [中图分类号]　R735 [文献标志码] A [文章编号]　1000-7431 (2013) 04-0378-04 Anvances in research on Raf kinase inhibitory protein in common digestive system malignant tumors YU Min，LÜ Nong-hua Department of Gestroenterology, First Affiliated Hospital of Nanchang University, Nanchang 330006, Jiangxi Province, China [A BSTRACT]　RKIP (Raf kinase inhibitor protein) is a member of PEBP (phosphatidylethanolamine-binding protein) family, which plays a pivotal modulatory role in MAPK (mitogen-activated protein kinase), GPCR (G-protein-coupled receptor) and NF-κB ( nuclear factor-kappaB) signaling transduction pathways. In recent years ，many studies reported that RKIP expression is weakened or lost in a series of malignant tumors such as prostate cancer, breast cancer and melanoma. RKIP may also play an important role in inhibition of tumor metastasis via inhibition of cell invasion and tumor angiogenesis. Recently, many experiments revealed that RKIP which is a metastasis-suppressor gene participates in the suppression of