新生儿甲状腺功能亢进症1例报道及文献复习.pdfVIP

J South Med Univ, 2013, 33(10): 1557-1558 doi 10.3969/j.issn. 1673-4254.2013.10.34 1557· · 病例报告 新生儿新生儿甲状腺功能亢进症甲状腺功能亢进症11例报道及文献复习例报道及文献复习 1 2 1 李 宁 ，李晓华 ，姚英民 1 2 南方医科大学南方医院新生儿科，广东 广州 510515；成都市妇女儿童中心医院新生儿科，四川 成都 610073 摘要：目的报道新生儿甲状腺功能亢进导致呼吸衰竭1例，并复习文献33 例。方法 自Medline 和CNKI 数据库检索国内外新 生儿甲亢病例报道。结果本病例为胎龄31+2 周早产儿，入院后第11天无明显诱因出现低热、心率增快、呼吸增快等，并因呼吸 衰竭给予呼吸机辅助通气，实验室检查证实为甲亢。后其母亦证实为妊娠合并甲亢。33 例中，心率增快、呼吸增快或体质量不 增是临床表现中最多见的。结论减少对孕母甲状腺疾病漏诊率及熟练掌握新生儿甲亢的临床表现是防止临床上漏诊或误诊 的关键。 关键词：新生儿；甲状腺功能亢进；误诊 Neonatal hyperthyroidism: a case report and literature review 1 2 1 LI Ning , LI Xiaohua , YAO Yingmin 1Neonatal Department, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China; 2Neonatal Department, Chengdu Women and Childrens Central Hospital, Chengdu 610073, China Abstract: Objective We report a case of neonatal thyrotoxicosis with concurrent respiratory failure in an infant born to a mother with Graves disease and review the published literature describing neonatal hyperthyroidism. The male infant who was born by spontaneous delivery at 35 weeks of gestational age presented with fever, tachycardia and tachypnea at rest on day 11 after birth, and developed severe apnea on day 14. Thyroid function studies revealed hyperthyroidism in the infant, and his mother was confirmed to have Graves disease during pregnancy. Literature review showed that among the 33 infants with similar conditions, tachycardia, tachypnea and poor weight gain were the most distinct clinical features of congenital hyperthyroidism. Accurate diagnosis of Graves disease in the mother during pregnancy and awareness of the clinical presentations of neonatal hyperthyroidism are key to reducing missed diagnosis or misdiagnosis of neonatal hyperthyroidism. Key