方案在乳腺癌新辅助化疗中的疗效及毒性对比分析.pdfVIP

第32 卷第4 期 安 徽 医 学 2011 年4 月 Anhui Medical Journal 449 TE 方案与TEC 方案在乳腺癌新辅助化疗中的疗效及毒性对比分析 桑 果 王本忠 ［摘 要］ 目的 比较TE 与TEC 方案在乳腺癌新辅助化疗中的近期疗效及毒副反应。 方法 63 例Ⅱ~Ⅲ期乳腺癌患者随机分为 两组，分别接受TE （多西他赛联合表柔比星）和TEC （多西他赛联合表柔比星及环磷酰胺）方案化疗，21 d 为1 周期，观察化疗后病理反应 并评价两组的近期疗效和毒副反应。 结果 TE 组与TEC 组有效率分别为84.4% （27/32）、87.1% （27/31），两者无显著差异。TEC 组Ⅱ~Ⅳ 度白细胞减少发生率、粒细胞缺乏性发热发生率均较TE 组高。 结论 TE 与TEC 方案在乳腺癌新辅助化疗中的疗效相似，TE 方案骨髓 抑制较TEC 方案轻，值得临床上广泛推广应用。 ［关键词］ 乳腺癌；新辅助化疗；毒副反应 doi ：10.3969/j.issn.1000-0399.2011.04.016 Comparison of the effectiveness of TE and TEC neoadjuvant chemotherapy regimen in breast cancer Sang Guo ，Wang Benzhong Department of Breast Surgery, No.1 Affiliated Hospital of Anhui Medical University,Hefei 230022,China [Abstract] Objective To compare and analyze the effect and side effect of two neoadjuvant chemotherapy regimens (TE and TEC). Methods The data of 63 female patients with Stage Ⅱand Ⅲa breast cancer was retrospectively analyzed. All patients were received neoadju－ vant chemotherapy with TE or TEC regimen before operation. Results Among all the 63 patients, 32 patients with breast cancer received TE regimen before operation, the rate of RR was 84.4% (27/32). 31 patients received TEC regimen, the rate of RR was 87.1%(27/31).In the differ－ ences of the clinical response rate between TE and TEC regimen, there were no significant differences.The side effect of TEC was more seriously, which mainly conclude leucopenia and alopecia. Conclusion The effect of the two neoadjuvant chemotherapy regimens(TE and TEC) are sim－ ilar. The bone marrow suppression of TE regimen is less seriously. It is recommended to utilized widespreadly in clinic. [Key words] Breast cancer ；Neoadjuvant chemotherapy ；Side effect 当前乳腺癌新辅助化疗方案并无统一标准，新辅助