加味四君子汤治疗脾气虚型常年性变应性鼻炎的临床疗效研究.pdfVIP

422 Chin0torhinolaryng0lJIntegMed2008，Vo1．16．No．6 加味四君子汤治疗脾气虚型常年性变应性鼻炎 的临床疗效研究术 唐月英 宋凯。 曾屹生 杨眉峰 【摘要l目的 研究加味四君子汤对脾气虚型常年性变应性鼻炎患者的治疗作用。方法 脾气虚型常年性变应性鼻炎患 者60例，随机分为实验组、西药对照组，每组各30例；另设缝康对照组30例。观察2组治疗前后总体疗效、血清IL一4、IL一12及 IFN-Y值变化有无显著性差异。结果 ①临床疗效上，实验组显著优于西药对照组 (PO．05)；②治疗前实验组、西药对照组 血清IL一4明显高于建康对照组，IFN—v、IL-12明显低于缝康对照组，(PO．01)；③治疗后，实验组、西药对照组血清IL．4均下 降，血清IFN—v均上升，实验组明显优于西药对照组 (P0．01)；实验组治疗后血清IL—l2明显升高，治疗前后有非常显著的差异 (PO．O1)，西药对照组血清IL一12治疗前后无显著差异 (PO．05)。结论 加味四君子汤对脾气虚型常年性变应性鼻炎具有较 好的临床疗效，临床上值得推广 【关键词】变应性鼻炎；加味四君子汤；疗效；临床研究 ClinicalobservationonthetherapeuticeffectofSupplementedFourGentlemen DecoctiononperennialallergicrhinitisinthepatternofSpleen—Qideficiency FANG Yueying, $0N6 lfai, ZEN6 Yisheng, fANGMeifeng TheSecondAffiiiatedHospitalofFujianTCM University,Fuzhou，350003,China [Abstract]0bjectiveToinvestigatethetherapeuticeffectofSupplementedFourGentlemenDecoction(DGD)onperennial allergicrhinitis(PAR)inaSpleen-Qideficiencypattem (SQDP)basedorlaclinicaltria1．MethodsIncludedinthisstudywere60cases withPARinSQDP,randomlydividedintotreatinggroup(TG)rteatedbyDGDandconrtollinggroup(CG)rteatedonlybychemicaldrugs， wiht 30casesnieachgroup．Furthermore，senllTlsamplesweretakenfrom htesecasesbeforeandafterthehterapyrespectivelytodetecthte changesnihtelevelsoflL-4，IL一12nadIFN-7inserum．Then，comparisonsweremadetoanalyzethedifferencesni thetotaleffectiverates nadhteserulrllevelchangesinIL一4，IL·12andIFN-7betweenhtetworgoups，wiht 30healthypersonsasthenormalreferences R『1for htedetectionofserum IL-4，IL一12nadIFN-7．ResultsTh etherapeuticeffectofTGwassignificantlysuperiortothatofCG．withmarked statisticalsignificancebetweenhtemfF0．05)．AscompraedwiththatofNKtheserumleveloflL-4wassignificnatlyhigherinbohtofTG andCG，whilethelevelsoflL一12nadIFN一．)，wereobviouslylowerthnahtatofNRfPO．O1)beforethehtemp~Byh