急性脑梗死患者血清超敏C反应蛋白及白介素6水平检测的临床意义.pdfVIP

国基星医药2011年8月第18卷第 15期 ChinJPrimMedPharm，August2011，Vo1．18，No．15 急性脑梗死患者血清超敏 C反应蛋 白 及 白介素6水平检测的临床意义 白爱国 摘【要】 目的 探讨急性脑梗死 (ACI)患者血清超敏C．反应蛋白(hs—CRP)和白介素-6(IL-6)水平的变 化及临床意义。方法 选择ACI患者90例，按梗死体积及神经功能缺损程度分组，应用免疫比浊法测定血清 hs-CRP水平 ，用ELISA法检测血清 IL-6水平并与对照组比较。结果 ACI组hs．CRP和IL-6水平明显高于健 康对照组(P0．05)。小梗死组、中梗死组、大梗死组患者血清 hs．CRP和 IL-6水平依次逐级升高(P 0．05)，轻型组、中型组 、重型组患者血清hs—CRP和 IL-6水平逐渐升高 (P0．05)。结论 ACI患者血清 hs． CRP和IL-6水平升高；血清hs—CRP和IL-6水平与脑梗死体积及临床神经功能缺损程度密切相关，检测hs． CRP和 IL-6有助于ACI患者病情及预后的判断。 【关键词】 急性脑梗死；高敏C一反应蛋白；白细胞介素．6；酶联免疫吸附法 Theclinicalsignificanceoftheserum levelsofhs·CRP and Ⅱ -6in patientswith acutecerebralinfarction BAIAi—guo．Departme~ofNeurology，ThePeoplesHospitalofQiheCounty，Shandong251100，China A【bstract】Objective Toinvestigatetheclinicalsignificanceoftheserumlevelsofhs—CRPandIL一6inpa． tientswithacutecerebralinfarction(ACI)．Methods 90patientswithAC1wereselectedanddividedintodifferent groupsaccordingtothesizeofinfarctionandclinicalneurologicimpairmentdergeescore．Theseurm hs—CRPlevelwas detectedbyimmunoturbidimetry，IL-6concentrationwasdetectedbyenzyme—linkedimmunosorbentassay(ELISA)． Results Thesernm hs—CRPandIL-6levelsinthepatientswithAC1weresingificnatlyhigherthna thatinthehealthy subjects(P0．05)．Comparingrgoupswiththedifferentinfarctionsize：theserumlevelsofhs—CRPnadIL-6werein— creasedsteplywiththevolumeofinfarction，thedifferencesbetweenthegroupsweresingificant(allP0．05)．Com— paringthethreergoups：thesernm levelsofhs-CRPandIL-6wereincreasedsteplywiththeclinicalneurologicimpair— mentdegreescore，thedifferencesbetweenthegroupsweresingificnat(allP0．05)．Conclusion Theserum!evels 0fhs—CRPnadIL-6weresignificantlyelevatedinthepatientswithACI．Th eserum levelsofhs—CRPandIL-6werein- creasedcloselywiththevolumeofinfarctionandtheclinical neurologicimpaimr entdegreescore，whichsuggeststhat hs—CRP nadIL-6 shouldplayan importantrolein thepathogenesisofACI，andprobablybeaprognosticfactorof ACI． 【Keywords】 Acutecerebralinfarction；C—reactiveprotein；Inte