复方磺胺嘧啶银乳膏的制备及应用.pdfVIP

维普资讯 2008年第 17卷第5期 复方磺胺嘧啶银乳膏的制备及应用 制剂技术 佟桂珍，佟桂芬 (辽宁省朝阳市中心医院，辽宁 朝阳 122000) 摘要：目的 改进传统磺胺嘧啶银乳膏的处方及制备工艺并制备复方制剂，以降低乳膏的黏稠度，提高制剂稳定性 ，增强乳膏抗菌、生肌效 果。方法 采用研合法，按照等量递加原则将药物粉末与乳膏基质 (o／w )调和均匀后制成乳膏，观察 60例烧、烫伤患者的疗效。结果 改进 后产品黏稠度适宜，易于涂布，质量可靠，临床有效率达 100％。结论 该制剂处方合理、制备工艺可行，疗效确切，值得推广。 关键词 ：磺胺嘧啶银 ；磺胺嘧啶锌 ；乳膏剂 ；制备 中图分类号：R944．2+1；R986 文献标识码 ：A 文章编号：1006—4931(2008)05—0027—02 Preparation and Application ofCompound SulfadiazineSilver Cream TongGuizhen，TongGufien fCentralHo@italofChaoyangCity,Chaoyang，Liaoning，China 122000) Abstract：0bjective To improve the prescription of the traditionalsulphadiazine silver cream and the technology ofpreparation，to nlanHfacture thecompound preparation forreducing the viscosity ofcream emulsion，increasing the stability ofthe preparation and enhancing the efiectofresisting bacterium and growing muscle．M ethods Adopting the methods of research compound，the medicinalpowder was blended with cream base fO／W 1 smoothly according tothe principle ofprogressively increasing in equalamount．To observe 60 casesof bum and scald patients’ effects in the treatmentResults The viscosity ofthe productwas suitable and easy to smear，the quality was reliable．The effective rate reached 100 percentin cliniealobservation Conclusion The prescription ofthe preparation is suitable The technology ofthepreparation isfeasible．The curati~e effectisreliable．Itmeritsspreading． Key words：sulphadiazine silver；sulphadiazinezinc；cream emulsion；preparatkm 磺胺嘧啶银乳膏为广谱抗菌药物，是我院临床治疗烧伤的常 沉淀能在氨试液 中溶解 。继续加硝酸，沉淀复生成。另取滤液约 用外用药，但按传统处方及工艺…配制，乳膏黏稠度较大，难 以涂 2mI，加亚铁氰化钾溶液即生成 白色沉淀，分离，沉淀在稀盐酸中 展和除脱 ，且抗菌、生肌效果较差 。为此 ，笔者对原处