血红素加氧酶 -1 与陷窝蛋白 -1 在疾病中的相互作用.pdfVIP

· 338 · 生命的化学, 2013, 33(3): 338-343 《生命的化学》2013 年33 卷3 期 综述 血红素加氧酶-1 与陷窝蛋白-1 在疾病中的相互作用 邹臣丹，邹朝霞，高旭* (哈尔滨医科大学生物化学与分子生物学教研室，哈尔滨150081) 摘要：血红素加氧酶-1(heme oxygenase-1, HO-1)是血红素分解代谢的限速酶，它与炎症、氧化应激以 及肿瘤的发生发展有着密切联系。HO-1 能够与陷窝蛋白-1(caveolin-1, Cav-1)的重要功能域相互作用。 Cav-1是一种细胞膜上的结构蛋白，其功能广泛，参与多种细胞信号的调节，且对于肿瘤发生发展有 多重作用。HO-1 与Cav-1不仅有共同作用的结构域，而且在多种细胞信号的调节中协同作用，探索 HO-1与Cav-1在疾病中的相互关系可能为确定HO-1在疾病中的功能提供新的思路。 -1 -1 关键词：陷窝蛋白 ；血红素加氧酶 ；肿瘤 Interactions between heme oxygenase-1 and caveolin-1 in diseases ZOU Chendan, ZOU Chaoxia, GAO Xu* (Deparment of Biochemistry and Molecular Biology, Harbin Medical University, Harbin 150081, China) Abstract: Heme oxygenase-1 (HO-1) is a rate-limiting enzyme in heme catabolism, which has intimate connection with many kinds of pathological mechanisms such as inflammation, oxidative stress, initiation and metastasis of tumors. Recent advance has revealed that HO-1 interacts with the crucial domain of caveolin-1 (Cav-1). Cav-1 is a multifunctional structural protein on cell membranes, participating in the regulation of plentiful signal transduction. It also manifests multiple functions in the initiation and development of tumors. These two molecules not only possess the domains with same function, but also display coordination in the regulation of ambivalent cellular signals. However, its mechanism of action is still unclear. Exploring the the complex mutual regulation and interrelationship between HO-1 and Cav-1 will provide a new insight into the role of HO-1 in diseases. Key words: Caveolin-1; Heme oxygenase-1; cancer 血红素加氧酶-1(heme oxygenase-1, HO-1)是血 调节细胞的增殖、炎症反应以及