早期帕金森病患者99Tcm-TRODAT-1多巴胺转运蛋白显像研究.DOCVIP

临床医学论文-早期帕金森病患者99Tcm-TRODAT-1多巴胺转运蛋白显像研究 ?????????????????????? 作者：张雄　李焕斌　张琦　王小同 【摘要】? 目的 研究早期帕金森病（parkinson disease，PD）患者99Tcm-TRODAT-1多巴胺转运蛋白SPECT显像的特点和诊断价值。方法 15例早期PD患者和10例对照者，分别进行99Tcm-TRODAT-1多巴胺转运蛋白（dopamine transporter，DAT）显像，观察其放射性分布特点，并利用半定量分析法，分别计算纹状体（striatum，ST）、尾状核（caudate nucleus，CN）及壳核（putamen，PT）与小脑（cerebellum，CB）的放射性计数比值。比较对照组和早期PD患者两侧纹状体及主要区域DAT功能差异。结果对照组ST/CB、PT/CB、CN/PD组对侧ST/CB、PT/CB、CN/CB分别为1.23±0.13、1.80±0.15、1.13±0.13;PD组同侧ST/CB、PT/CB、CN/CB分别为1.79±0.13、1.86±0.15、1.78±0.14。PD组对侧与对照组比较，其中ST/CB、PT/CB差异均有统计学意义（t=10.83、15.21，P均0.05）;而CN/CB差异无统计学意义（t=1.96，P0.05）。PD组对侧与PD组同侧比较，其中ST/CB、PT/CB差异均有统计学意义（t=10.55、11.69，P均0.05）;而CN/CB差异无统计学意义（t=1.08，P0.05）。结论早期PD患者存在着患肢对侧ST、PT区的DAT放射性摄取值的下降，因此99Tcm-TRODAT-1多巴胺转运蛋白SPECT显像可作为PD早期诊断的客观诊断指标之一。 【关键词】? 帕金森病 多巴胺转运蛋白 99Tcm-TRODAT-1 SPECT ??? SPECT image of dopamine transporter in early stage of Parkinsons disease ZHANG Xiong，LI Huanbin，ZHANG Qi，et al.Department ofNeurology，the Second Affiliated Hospital ofWenzhouMedical College，Wenzhou325027，China【Abstract】Objective To investigate the clinical values of99Tcm-TRODAT-1SPECT dopamine transporter（DAT）imaging in the diagnosis of early stage Parkinsons disease（PD）.Methods Fifteen early stage PD patients and10age matched healthy volunteers were recruited.Brain SPECT imagingwas performed at180min after intravenous injection of99Tcm-TRODAT-1.The DAT levels of the striatum（ST）and its subregions，including the putamen（PT）and caudate nucleus（CN），were calculated by semi-quantity region of interest（ROI）technique with the radiation ratios of target/cerebellum（CB）.All the ratios of PDwere compared with that of the two sides（ipsilateral and contralateral to the affected limb）and that of healthy volunteers.Results The radiation ratios of ST/CB，PT/CB，CN/CB were1.90±0.18，1.92±0.15，1.87±0.10respectively in healthy volunteers group，while were1.23±0.13，1.80±0.15，1.13±0.13in group of contralateral side to the affected limb，and were1.79±0.13，1.86±0.15，1.78±0.14in group of ipsilateral to th