消化性溃疡病人血清中IL-17和IL-25的水平变化及意义.DOCVIP

临床医学论文-消化性溃疡病人血清中IL-17和IL-25的水平变化及意义 ???????????????????????? 作者：陈霞，吕昌龙，李成，王大南 【摘要】? 目的 观察消化性溃疡病（peptic ulcer）患者外周血中IL-17和IL-25水平的变化,探讨IL-17和IL-25在消化性溃疡病中的作用。方法 采用ELISA法测定20例消化性溃疡患者及34例健康体检者血清IL-17和IL-25的含量。结果 消化性溃疡病患者和健康体检者血清IL-17的水平分别为（197.79±25.77）pg/ml和（174.85±27.38）pg/ml，差异无显著性（P0.05）。血清IL-25的水平分别为（1051.58±185.96）pg/ml和（837.73±107.66）pg/ml，差异有显著性（P0.01）。消化性溃疡病患者中包括十二指肠球溃疡12例和复合溃疡8例，血清中IL-17的水平分别为（222.19±32.98）pg/ml和（161.17±27.00）pg/ml，十二指肠球溃疡病人血清中IL-17的水平明显高于健康体检组（P0.01），复合溃疡组的IL-17水平与健康体检组比较差异无显著性（P0.05）。血清IL-25的水平分别为（1011.65±122.63）pg/ml和（1111.49±151.79）pg/ml, 与健康体检者比较差异均有显著性（P0.05）。结论 消化性溃疡病人外周血中IL-17和IL-25均可发生有意义的变化，提示该两种细胞因子参与消化性溃疡病的炎症过程；IL-25的水平升高较IL-17更为明显，提示 IL-25水平的变化可能与消化性溃疡病发生发展关系更为密切。 【关键词】? IL-17;IL-25;消化性溃疡 ??? 【Abstract】? Objective? To investigate the changes and clinical significance of interleukin 17（IL-17） and IL-25 levels in serum from patients with peptic ulcer.Methods? The levels of IL-17 and IL-25 in the serum from 20 patients with peptic ulcer （including 20 patients with duodenal ulcer and 8 with complex ulcer）and 34 health control were detected by enzyme-linked immunosorbent assay （ELISA）.Results? The level of IL-17 was（197.79±25.77）pg/ml in the patients and（174.85±27.38）pg/ml in the control repectively, no significant difference betreen the two groups（P0.05）. The level of IL-25 in the patients （1051.58±135.96）pg/ml was significant higher than that in the control（837.73±107.66）pg/ml（P0.01）. The level of IL-17 in 12 patients with duodenal ulcer（222.19±32.98）pg/ml is significantly higher than that in the control（P0.01）, but no difference between the group of 8 patiets with complex ulcer（161.17±27.00）pg/ml and the control（P0.05）. The levels of IL-25 in both groups with duodenal（1011.65±122.63）pg/ml and complex（1111.49±151.79）pg/ml ulcer are significantly different from that of the control group（P0.05）.Conclusion? The level of cytokines IL-17 and IL-25 in sera from the patients with peptic ulcer were showed to be significantly increased, in