一个基于熵的对疾病基因精细定位的指数.pdfVIP

Journal of Genetics and Genomics (Formerly Acta Genetica Sinica) July 2007, 34(7): 661668 Research Article An Entropy-based Index for Fine-scale Mapping of Disease Genes Yumei Li 1, 3,, Yang Xiang 2, 3, Hongwen Deng 4, 5, Zhenqiu Sun 1 1. School of Public Health, Central South University, Changsha 410078, China; 2. College of Mathematics, Central South University, Changsha 410081, China; 3. Mathematics Department of Huaihua College , Huaihua 418000, China; 4. College of Life Sciences, Hunan Normal University, Changsha 410081, China; 5. Departments of Orthopedic Surgery and Basic Medical Science, School of Medicine, University of Missouri-Kansas Kansas MO 64108, USA Abstract: By comparing the entropy and the conditional entropy in a marker, an entropy-based index has been presented for fine-scale linkage disequilibrium gene mapping using high-density marker maps for human disease genes. The index can quantify the level of linkage disequilibrium (LD) between the marker and the disease susceptibility locus (DSL) of genes. The advantage of using the index is attributed to the fact that it does not depend on marker allele frequencies across loci. Moreover, it is parallel to Hardy-Weinberg disequilibrium (HWD) measure for DSL fine mapping. Through various simulations, the fine mapping perform- ances of the proposed entropy-based index was extensively investigated under various genetic parameters. The results show that the index presented is both robust and powerful for DSL mapping in genes. Keywords: entropy; entropy-based index; fine mapping Fine-scale mapping plays an important role in tients, linkage disequilibrium (LD) methods in iso- positional cloning of genes responsible for several lated populations have been used[3]. With constant diseases