Name of journal World Journal of Gastroenterology ESPS Manuscript NO 10351 Columns RESEARCH REPORT I.docVIP

?? Increased expression and possible role of chitinase 3-like-1 in a colitis-associated carcinoma model Jia-Yi Ma, Run-Hua Li, Kun Huang, Gao Tan, Chen Li, Fa-Chao Zhi CITATION Ma JY, Li RH, Huang K, Tan G, Li C, Zhi FC. Increased expression and possible role of chitinase 3-like-1 in a colitis-associated carcinoma model. World J Gastroenterol 2014; 20(42): 15736-15744 URL /1007-9327/full/v20/i42/15736.htm DOI /10.3748/wjg.v20.i42.15736 OPEN ACCESS Articles published by this Open-Access journal are distributed under the terms of the Creative Commons Attribution Non-commercial License, which permits use, distribution, and reproduction in any medium, provided the original work is properly cited, the use is non commercial and is otherwise in compliance with the license. CORE TIP Increased expression of chitinase 3-like-1 (CHI3L1) mRNA was found in ulcerative colitis patients with dysplasia. It is not known whether CHI3L1 contributes to inflammation-driven carcinogenesis. Our study showed increased expression of CHI3L1 during the progression of carcinogenesis. Caffeine protected against severe inflammation and neoplasms by acting as a scavenger of reactive oxygen species (ROS), which may be partly attributed to CHI3L1 inhibition. In vitro data showed that CHI3L1 increased ROS production in colonic epithelial cells under conditions of oxidative stress. Our study has made a modest advance in the exploration of CHI3L1 in colitis-associated carcinoma. KEY WORDS Inflammatory bowel disease; Ulcerative colitis; Colitis-associated carcinoma; Murine model; Chitinase 3-like-1; Oxidative stress; Colorectal cancer COPYRIGHT ? 2014 Baishideng Publishing Group Inc. All rights reserved. COPYRIGHT LICENSE Order reprints or request permissions: bpgoffice@ NAME OF JOURNAL World Journal of Gastroenterology ISSN 1007-9327 (print) 2219-2840 (online) PUBLISHER Baishideng Publishing Group Co., Limited, Flat C, 23/F., Lucky Plaza, 315-321 Lockhart Road, Wan Chai, Hong Kong, China