Recent advancement in Mouth Dissolving Drug Delivery System.docVIP

Recent advancement in Mouth Dissolving Drug Delivery System Shikha Baghel Chauhan* and S.S. Agrawal Amity Institute of Pharmacy, Amity University, Noida,-201301, India. *Corresponding author Shikha Chauhan Assistant Professor, Amity University, Email: shikha.pharma@, schauhan@ Mobile No. 9873495966 Abstract : Methods to improve patient’s compliance have always attracted scientists towards the development of advanced Oral drug delivery systems. Among them, mouth dissolving drug delivery systems (MDDDS) have acquired an important position in the market by overcoming previously encountered administration problems and contributing to extension of patent life. MDDDS have the unique property of rapidly disintegrating and dissolving and releasing the drug as soon as they come in contact with saliva, thus obviating the requirement of water during administration. Therefore, these dosage forms have lured the market for a certain section of the patient population specially for the geriatric and paediatric patients. Several techniques have been developed in the recent past, to improve the disintegration quality of these delicate dosage forms without affecting their integrity. This review article focuses on the advanced technologies developed and the advances made in the field of fabrication of mouth dissolving tablets Key words : Mouth Dissolving, Fast Disintegrating, Lyophilization Introduction Designing improved version of existing medicine into a novel drug delivery system can significantly improve its performance in terms of efficacy, safety improved patient compliance Tablet is the most popular among all dosage forms existing today because of its convenience of self administration, compactness and easy manufacturing but in certain cases as that of uncooperative patients, the problem of swallowing is common phenomenon which leads to poor patient compliance1. The concept of Mouth Dissolving drug delivery system emerged with an objective to enhance patient’s