超临界流体强化溶液分散法制备L-聚乳酸微粒.pdfVIP

JournalofPharmaceuticals201 中国医药工业杂志Chinese 1。42(3) 超临界流体强化溶液分散法制备L．聚乳酸微粒 陈岚，乔培，高丹丹，刘哲鹏 (上海理工大学医疗器械与食品学院，上海200093) 摘要：利用超临界流体强化溶液分散法(SEDS法)制备了生物可降解L．聚乳酸(PLLA)微粒，研究不同压力、温度及 溶液浓度条件下所制备微粒的大小、形态和分布情况。实验表明：微粒平均粒径为5～26 Ixm，呈球形；微粒粒径和粒 径分布随压力的升高而减小，随浓度的增大而增大，温度对微粒粒径的影响不显著。超临界体系中PLLA玻璃化转化温 度的降低对微粒影响较大，使微粒粒径变大，粒径分布变宽。高压低温有利于产生粒径小且分布均匀的球形微粒。 关键词：超临界流体；L-聚乳酸；超临界流体强化溶液分散法；微粒；药物载体 中图分类号：TQ460．4文献标志码：A 文章编号：100I．8255(2011)03-0193—05 of SEDSProcess PreparationPoly(L—lactideacid)Microparticlesusing CHEN Lan，QIAOPei，GAODandan，LIU Zhepeng Instrument and (School Science 200093) ofMedical andFoodEngineering,UniversityofShanghaiforTechnology,Shanghai acid)(PLLA)biodegradable were solution- ABSTRACT：Poly(L—lactide polymermicroparticlespreparedusing enhanced fluids(SEDS)．Theinfluencesof andconcentrationof dispersionbysupercritical pressure，temperature PLLAsolutiononthe anddistributionof werestudied．Themeandiameterofthe size，morphology microparticles was5-26 sizeof decreasedasthe increased．andthesize sphericalmicroparticlespm．The microparticles pressure andthedistributionof increasedastheconcentrationincreasedbutwerenot affected microparticles significantlyby couldbeaffectedwiththedecreaseof transition ofPLLAinthe systemtemperature．However,they glass temperature in sizeandwiderdistr