复方乌连提取物镇痛、抗炎、止泻的药效学研究.pdfVIP

浙江中医药大学学报20 14 年4 月第38 卷第4 期 复方乌连提取物镇痛、抗炎、止泻的药效学研究 1 1 2 李海清 吕圭源 陈素红 1.浙江中医药大学 杭州 310053 2.温州医科大学 摘要：[ 目的]观察复方乌连提取物的镇痛、抗炎、止泻等药效学作用。[方法]分别采用热板法、醋酸扭体法、甲醛刺激观察镇痛作用，二甲苯致小鼠耳 J O 廓肿胀法、醋酸致腹腔毛细血管通透性增高法观察抗炎作用；番泻叶和蓖麻油致腹泻法观察止泻作用。[结果]复方乌连提取物能抑制由高热、醋酸 U R 以及甲醛刺激所致的小鼠疼痛；抑制二甲苯引起的小鼠耳廓肿胀和醋酸引起的小鼠腹腔毛细血管通透性增加；同时能延长番泻叶与蓖麻油引起的 N A L 小鼠腹泻潜伏期，并能减少小鼠腹泻次数。[结论]复方乌连提取物具有显著的镇痛、抗炎、止泻作用。 O 关键词：中药复方；镇痛；抗炎；止泻 F 中图分类号：R282.71 文献标识码：A 文章编号：1005-5509（2014 ）04-0456-05 Z H 1 1 2 E To Study the Analgesic, Anti-diarrhea and Anti-inflammatory Effects of Wulian Compound Extract Li Haiqing ,Lv Guiyuan ,Chen Suhong 1. J I A Zhejiang Chinese Medical University, Hangzhou(310053), China; 2.Wenzhou Medical University N G Abstract: [Objective] To study the analgesic, anti-diarrhea and anti-inflammatory effects of Wulian compound extract. [Method] To study the analgesic C effect of Wulian compound extract on mice with hot －plate test, writhing test, and formaldehyde stimulation. To study the anti-inflammatory effect of H I N Wulian compound extract by mice ear －swollen induced by xylene and abdominal cavity capillary Permeability text ．To study the anti-diarrhea effect of the E S Wulian compound extract with the method of diarrhea induced by castor oil and senna. [Results] Wulian compound extract can inhibit the pain caused by E M high fever, acetic acid and formaldehyde. Inhibit the xylene induced ear swelling of mice and increase of celiac capillary permeability induced by acetic E acid. At the same time Wulian com