复方氟米松软膏治疗寻常性银屑病有效性与安全性评价.pdf

444I 纛lM第20a2Y140卷2~{0第5105嬲Vol2。4，No5 复方氟米松软膏治疗寻常性银屑病 有效性与安全性评价 刁庆春 ，柯丹 ，陈德宇。，向光。，刘涛 ，黎斌 ，薛梅 ，向进 ，吕静 ，张洁 [摘 要] 目的 观察复方氟米松软膏治疗寻常性银屑病的疗效和安全性。方法 将 140例寻常性银屑病患者 分为治疗组 (复方氟米松软膏2；L／d外用)、对照组 (糠酸莫米松软膏2次／d外用)各70例，采用多中 心、随机、阳性药物平行对照的方法进行临床观察，观察时间为4周。结果 治疗4周时两组患者的痊 愈率分别为24．28％和 15．7l％，有效率分别为77．14％和 58．57％，治疗组的有效率明显高于观察组， 差异有显著性 (P0．05)，两组均未发现明显不 良反应。结论 复方氟米松软膏是一种安全有效的治 疗寻常性银屑病的外用药物。 [关键词] 银屑病，寻常性；复方氟米松软膏；安全性；糠酸莫米松；多中心随机对照试验 [中图分类号] R758．63 [文献标识码] B [文章编号] 1001—7089(2010)05—0444—02 TheEvaluationofEffi cacyandSafetyofCompoundFlumetasoneOintmentfortheTreatmentofPsoriasisVulgaris DIAOQing—chun’，KEDan’，CHENDe—yu，XIANGGuang，LIUTao，LIBin，XUEMei，XIANGJin，LVJing， ZHANG Jie (1．DepartmentofDermatology，theFirstPeopleHospitalofChongqing，Chongqing400011，China；2．DepartmentofDer— matology，theAffiliatedHospitalofLuzhouMedicalCollege，Sichuan646000，China；3．DepartmentofDermatology，the SecondAffiliatedHospitalofThreeGorgeMedicalSchool，Chongqing404000，China) [Abstract] Objective ToevaluatetheefficacyandsafetyofCompoundFlumetasoneOintmentforthetreatmentofpso— riasisvulgaris．M ethods A randomizedmuhicenterclinicalstudywithpositivecontrolwasca~iedout．One hundredandfortypatientswithpsoriasisvulgarisweredividedintotwogroupsandtreatedofrfourweeks．The treatmentgroupwastreatedwithCompoundFlumetasoneOintmenttherapy(B．i．d)andthecontrolgroup wastreatedwithElocon(B．i．d)．Results Thecurativerateswere24．28％ inthetreatmentgroupand 15．71％ inthecontrolgroup．Theefficacyrateswere77．14％ and58．57％ respectively．Theefficacyrate oftreatmentgroupwerehigherthanthatofcontrolgroup(P0．05)．Therewasnotadversereactionoccured inbothtwogroups．Conclusions CompoundFlumetasoneOintmentisaneffectiveandsafetopicalagentfor thetreatmentofpsoriasisvulgaris． [Keywords] Psoriasisvu