副流感病毒小鼠动物模型的建立及病理学研究_杜淑娟.pdfVIP

2006 7 July, 2006 16 　7 CHINESE JOURNAL OF COMPARATIVE MEDICINE Vol.16　No.7 1 2 1 杜淑娟, 程树军, 袁美凤 (1., 　510120;　2., 　510623) 　　【】　　, 。 　 NIH、BALB c M , 。 　 M , , , , 。 　 M , 。 【】　;;, 【】R56　　【】A　　【】1671-7856(2006)07-0387-03 Pathology Study and Model Foundation of Parainfluenza Virus Infection in Mice 1 2 1 DU Shu_juan , CHENG Shu_jun , YUAN Mei_feng (1.Guangdong Hospital of TCM, GuangZhou 510120, China;　2.Guangdong Entry_Exit Inspection and Quarantine Technique Center, GuangZhou 510623, China) 【Abstract】　Objective　To establish a parainfluenza_virus_infective modelinmice andto provid model animals for anti_vir- us research of TCM.Method　NIH, BALB c and M micewere infected by Sendia virus (SV), whose antigen were closed to parainfluenza virus.Then the change of histopathological was observed.Result　The M micewas an ideal strainfor SV infection for its moderate infection duration, obvious clinical symptoms and typical lesion.Conclusion　SV_infected M mice can be used in model of anti_parainfluenza virus infected disease and pharmacology researches. 【Key ords】　Sendia virus;Parainfluenza virus;Model, animal 　　ⅠⅢ 1　 , 26%, 1.1　 [ 1] 。 NIH、BALB c M 40 , , 。 (: , A0010244), 13 ～ 15 g, 。 。 , 、、 , 20。 [2] 。 1.2　 , (Sendiavirus SV)