MicroRNA与人类血液系统疾病的研究进展.pdfVIP

中国实验血液学杂志 Jou rnal of Expermi ental H em ato lo y 2008; 16( 4): 979- 983 # 979# (Article ID): 1009- 2137(2008)04- 0979- 05 # # M icroRNA 孟冬梅, 苗志敏 青岛大学医学院附属医院血液科, 山东青岛 266003 m icroRNA (m iRNA ) 是一类长约 22 nt( 19- 25 nt)在进化方面属保守的非编码 RNA s, m iRNA 与靶 m RNA 3c端非翻译区序列 完全互补结合, 抑制翻译, 在转录后水平调控靶基因的表达m iRNA 在人体内发挥着非常广 泛而重要的调控作用本文对m iRNA 的特征功能特点及在人类血液系统肿瘤发生中的作用等方面的研究进展 进行综述 m icroRNA; 基因调控; 血液系统肿瘤 Q 522; R733 A Research Progress of M icroRNA s and Human H ematologicalD iseases ) ) ) Rev iew M ENG Don -M ei, M IAO Zhi-M in D epartm ent o fHem ato lo y, TheA ffiliated H ospita l, M edica lC o lle e, Q in dao Un iversity, Q in dao 266003, Shandon P rovince, Ch ina Abstract The m icroRNA s ( m iRNA s) are an evolu tionarily con served class of 22 nucleotide ( 19 - 25 n t) non- cod in RNA s. The m iRNA s are partially com p lem en tary to 3c untran slated re ion of tar et mRNA, resultin in the repression of ene expression at post-transcriptional level. The m iRNA s have been associated w ith diverse b iolo ical processes. Th is review summ arizes recent pro ress of research on the characteristics and function of m iRNA s, and the ro le of m iRNA s in hem ato lo icalm ali nancy developm ent. Key words m icroRNA; ene re ulation; hem atolo icalm ali nancy J Exp H em atol 2008; 16( 4): 979- 983 [ 1] 1993 Lee (Caenorhabditis RNA, m iRNA ele ans) () , m iRNA RNA - lin-4, 1 2 ( pr-im iRNA ) RN ase Ó D rosha [ 2] 2000 R einhart 70- 100 nt RNA - let-7, 3 m iRNA ( pre-m iRNA s) [ 4] pre-m iRNA 4,