不同时程APP转基因小鼠学习记忆_省略_及参乌胶囊_二苯乙烯苷的干预作用_张兰.pdfVIP

2006 3 15 3　Chin J of BehavioralM e Sc,iM arch 2006, Vol 15, No. 3 193 APP 、 张兰 邢颖 赵玲 叶翠飞 艾厚喜 李林 【】 (A lzheimer’ s isease, AD) , (TSG) AD。 AD 4 16 APP695V717I。 4 TSG 6 。 APP 10 TSG 6。 C57BL /6J。 M orris。 4APP , 46. 1%, 2. 96 。 10 , , APP, 95%, 6. 7。 16, 10。APP , , 49. 1%, 2. 95。 TSG 10APP M orris, 。 10 TSG 6, 16 APPM orris , 。 4、10、16APP695V717 I 、、AD , AD AD 。 , , AD。 【】 ; APP; ; ; Learningmemory deficit in APP transgenicmodel ofA lzheimer’ s disease and intervention by Shen-wu capsuleand its effective component ZHANGLan, X INGYing, ZHAO Ling, et al.D ept. Pharmacology, X uan- wu hosp italof apitalUniversiyt ofMedicalSciences, BeijingKey Laboratory forB rain Aging, B eijing 100053, h-i na 【Abstract】 Objective To investigate learn ing-m emory eficit in the ifferen t age ofAD-like anmi almo el an the protective effect of Shen-wu capsu le an its effective com ponen-t 2, 3, 5, 4-tetrahy roxy stilbene-2-O-β-D- glucosi e(TSG )on learn ing-m emory ability. M ethods AD-like APP V717I transgenic(Tg)mouse was observe from 4 to 16 m onth s ol . The Tg m ice were ran om ly ivi e into 3 m o el groups(4 months 10 m onths an 16 m on ths ol ), Shen-wu capsu le group an TSG group. The an mi alsw ere a m in istere intragastrically by the rugs from 4 to 10 m onths ol . For un-treate 10 m on ths APP Tg m ice, TSG w ere a m in istrate to them from 10 to 16 m on ths ol . Control a apte the sam e age an backgroun C57BL /6Jm ice. Learning-m em ory ab ility w as etecte byMorriswaterm aze(MWM )an object recognition test(ORT). Results For 4 m on th ol APP Tg m ice, learn- ing-m em ory eficit appeare . The sw imm ing tmi e an istance increase in MWM an the iscrim ination in ex e- crease in ORT. For 10 m onths ol APP Tg m ice, learning-m em ory eficit aggravate . Both Shen-w u capsu le an