复合磷脂脂质体作为温敏靶向载体研究.pdfVIP

第五届江苏省热分析学术研讨会暨地热分析术论坛及仪器展示会重 D 重 复合磷脂脂质体作温敏靶向载体的研究 陈军，何超芹，董莹，蔡宝昌 南中药大学药学院，南染该古口口该韦染 摘染摘染要要目的闭染利用复合磷脂氢大豆磷脂旻锆萃零和棕榈磷脂胆碱雷萃萃零组技术 摘摘染染要要 优温敏脂质体的处方提高温敏释性能方法闭染采用薄膜水法制备钙黄绿素脂质体， 利用钙黄绿素的荧自淬灭特性考察脂质体的温敏释特性，确复合磷脂脂质体的处方， 并常规的雷萃萃零温敏脂质体较在释质中的温敏释性能荷瘤小鼠模型， 较马钱子碱雷萃萃零温敏脂质体复合磷脂脂质体的靶向递效果结果闭染温敏 脂质体相，于复合磷脂技术制备的温敏脂质体的相温度切造雷萃萃零温敏脂质体 高该℃，在溶血磷脂退锆萃零用少了巩口还的条，在释质中，均雷萃萃零温敏 脂质体更优的温敏释性能复合磷脂脂质体的温敏温敏脂质体在小鼠血浆中的释人血 浆中的释最接组结果显示马钱子碱复合磷脂脂质体在热瘤中的浓度是 热瘤的该倍结论闭染复合磷脂脂质体能够少退锆萃零用，更好的温敏释性能和靶向 递效果染 关键词关键词复合磷脂脂质体问钙黄绿素问染温敏释问溶血磷脂马钱子碱染 关键词关键词 染 Study on liposomes composed of DPPC and HSPC as novel thermosensitivecarriers for targeting drug delivery Jun Chen, Chao-qin He, Ying Dong, Bao-changCai (School of pharmacy, Nanjing University of Chinese Medicine, Nanjing 210023) ABSTRACT(D):OBJECTIVE:To optimize the prescription of the novel temperature-sensitive liposomes. METHODS:Calcein-loaded temperature-sensitive liposomes with different phospholipid composition were prepared by the thin film –hydration method. Based on the fluorescence self-quenching off characteristics of calcein, the release behavior of the above liposomes was compared when exposed to 37 ℃ (normal temperature) as well as their respective phase transition temperature (Tm) ，determine prescription of novel temperature-sensitive liposomes,investigate the release of liposomes at different release media, to determine the appropriate release medium . RESULTS:Compared with the traditional temperature-sensitive liposomes, the NTSL showed more favorable temperature-sensitive release performance and more stable encapsulation ability to calcein, even with the amount of lysophospholipids was reduced by 60 percent;The release of in mouse plasma is closed to release in human plasma ; the stu