儿童感染肺炎链球菌的分布及耐药性分析.pdfVIP

·16· 中国实用医药20 14年8月第9卷第22期　China Prac Med, Aug 20 14, Vol. 9, No. 22 儿童感染肺炎链球菌的分布及耐药性分析 刘华林　胡丽娟　刘华山 【摘要 】　 目的　分析儿童肺炎链球菌 (SP) 对常用抗生素 的耐药情况 。方法　采用法 国梅里埃公 司的 VITEK 2 Compact 全 自动细菌鉴定仪对本院 20 13 年儿童感染 SP 分离情况及抗菌药物敏感性进行 回 顾性 的分析。结果　痰液、咽拭子为 SP 主要标本来源 , 分别 占 96.4% 和 2.9% ；在 280 株 SP 中对常用 抗菌药物的耐药率有普遍上升趋势 , 其 中对红霉素、四环素、复方新诺 明的耐药率较高 (80%), 对青霉 素类和三代头孢类 的耐药率较低 (40%), 对氯霉素、泰利霉素和美罗培南 的耐药率更低 (10%), 对利奈 唑胺 、万古霉素、厄它培南和氟喹诺酮类均无耐药性 。结论　加强对 SP 的耐药性检测 , 以指导临床医 生制定合理有效的治疗及用药方案 。 【关键词 】　肺炎链球菌 ；儿童 ；耐药性 Distribution of children-infected streptococcus pneumoniae and drug resistance analysis LIU Hua-Lin, ’ HU Li-Juan, LIU Hua-Shan. Department of Pediatrics, Putian Children s hospital, Putian 351100, China 【Abstract 】　Obj ective To analyze the drug resistance of streptococcus pneumoniae(SP) to commonly used antibiotics in children. Methods Retrospectively analyzed the separation of children-infected SP and the resistance to antibiotics using VITEK 2 compact automated bacterial identification system provided by French Merieux. Results Sputum and throat swab specimens were the main source of SP, accounting for 96.4% and 2.9% respectively; the 280 strains of SP showed a generally increased trend in drug resistance to commonly used antibiotics, higher resistance rates were observed for erythromycin, tetracycline and trimoxazole (80%), the rate of resistance to penicillin and third generation cephalosporins was low (40%), resistance to chloramphenicol, meropenem and telithromycin rates lower (10%), no evidence of resistance to linezolid, vancomycin, imipenem and fluoroquinolones. Conclusion Strengthened test for the drug resistance of SP can guide clinicians to make rational and effective treatment and medication.