头孢哌酮致过敏性紫癜1例.pdfVIP

头孢哌酮致过敏性紫癜1例 赵玉芬，张新明，陈军林 (同济大学附属上海第十人民医院药剂科，上海200072) [摘要】 1例老年女性因急性胆囊炎入院。患者静脉滴注克林霉素600mg，qd和头孢哌酮2g，bid抗 感染。次日左臂出现皮疹伴皮下出血点，考虑与头孢哌酮有关，停用该药。1周后因感染仍未控制，再次静 脉滴注头孢哌酮，出现全身性皮疹，且血小板下降低于正常范围，诊断过敏性紫癜，立即停用头孢哌酮。d2 mmol·L～。给予 患者血肌酐由入院时205 mmol·L一升至23．6 ttmol·L。1升至464trmol·L～，尿素氮由13．5 X 甲泼尼龙、氯雷他定抗过敏治疗，4周后血小板回升至正常范围(84×109·L_1升至136109·L-1)，皮疹消 退，肾功能好转。 【关键词] 头孢哌酮；过敏性紫癜；药物不良反应 【中图分类号]R978．1[文献标识码]B case sodium：one Anaphylactoidfollowingcefoperazone report purpura ZHAO Yu—fen，ZHANG Jun—lin Xin—ming，CHEN Tenth 200072，China) (DepartmentofPharmacy，ThePepolesHospitalofShanghai，TongjiUniversity，Shanghai A womanwithacute wasadmittedintothe wasadminis— [Abstract] 70一years—old eholecystitis hospital．She teredwithintravenousinfusionof sodium(2．0 thetreat— clindamycin(600mg，qd)andcefoperazone g，bid)for mentofinfection．Skinrash subcutaneousonleftarnlwasfoundnext accompaniedby bleeding sodiumwaswithdrawnfor theassociationwiththis the was tocefopera- considering drug．Whenpatientreexposed zonesodiumfor oneweek skin thePI』Tdecreased theinfection later，she rash，and controlling presentedsystemic belownormal was sodiumwas limits．The anaphylact