中药复方胃力康胶囊对实验性胃溃疡作用研究.pdfVIP

InfluenceofMDA,LDH,VEGFofonfocalcerebralischemiainratsofYiyintongluoCapsule BaiLiming1YangXiuqing1ZhangXiaoshuang2BaiLu2 1AffiliatedHospitalofShaanxiUniversityofChineseMedicine,Xianyang 712000 2ShaanxiUniversityofChineseMedicine,Xianyang 712046 Objective:Tostudytheinfluenceofmalondialdehyde(MDA),lactatedehydrogenase(LDH)contentofserum,brainvascularendothelial growthfactor(VEGF)ofonfocalcerebralischemiamodelinratsofYiyinTongluocapsule.Method:Thelocalcerebralischemiainratwas madebymiddlecerebralarteryocclusion,Successfulmodelratswererandomlydividedintoshamoperationgroup,modelcontrolgroup,Yiyin Tongluocapsulelarge,mediumandsmalldosegroupandpositivegroupofsixgroupsaccordingtoneurologicalscore.Aftertreatmentfortwo weeks,Measuredneurologicalscore,thecontentsofMDA,LDHcontentofserumandVEGFbyimmunehistochemicalmethod.Results:high dosegroup(10.8g/kg)andmiddledosegroup(5.4g/kg)ofYiyinTongluocapsulecandecreaseneuralbehavioralscore(P＜0.01);high-dose group(10.8g/kg),middledosegroup(5.4g/kg)andsmalldosegroup(2.7g/kg)candecreaseMDAandLDHcontentofserum;high-dose group(10.8g/kg),middledosegroup(5.4g/kg)andsmalldosegroup(2.7g/kg)canincreaseVEGFcontentinbrain(P＜0.05).Conclu sion:YiyinTongluocapsulehasprotectiveeffectonfocalcerebralischemiainrats,anditsmechanismmayberelatedtofreeradical,promote theformationofnewbloodvessels. YiyintongluoCapsule(益阴通络胶囊);focalcerebralischemia;malondialdehyde;lactatedehydrogenase;brainvascularendo thelialgrowthfactor 中药复方胃力康胶囊对实验性胃溃疡的作用研究 吕鹏1,2鄢良春1赵军宁1 1四川省中医药科学院 ·国家中医药管理局中药质量生物评价重点研究室·中药品质评价与创新中药研究 四川省重点研究室，成都6100412泸州医学院药学院，泸州646000 目的：研究胃力康胶囊(WLK)对实验性胃溃疡 (GU)的防治作用和作用机制 。方法：采用小鼠水浸束缚应激性胃溃 疡和大鼠乙酸灼烧型胃溃疡模型进行实验，观察小鼠溃疡指数及各组大鼠溃疡面积；常规HE染色和免疫组化，观察胃力康胶囊对 胃组织病理变化和核转录因子κB-p65(NFκB-p65)和白细胞介素-8(IL-8)蛋白表达的影响。结果：胃力康胶囊3个剂量组(9.198g、 18.396g、36.792g(原生药)/kg）及胃力康颗粒组 （36.792g(原生药)/kg）对小鼠水浸应激性胃溃疡具有显著