多西他赛联合低剂量顺铂治疗晚期高龄非小细胞肺癌的临床研究.pdfVIP

·52· 肿瘤防治研究2008年第35卷第1期 ·临床应用· 多西他赛联合低剂量顺铂治疗晚期高龄 非小细胞肺癌的临床研究． 郭仁宏1，唐桂棣1，潘良熹1，黄新恩1，冯继锋1，张全安2 ClinicalObservationofDoeetaxelCombinedwithLow-dose for Advanced Treating Cisplatin Non-smallCell Cancerin Patients Lung Elderly GUO Ren-hong，TANGGui-dil，PAN Xin-enl，FENG QI塌心a砰 Liang-xiI，HUANGJi-fen91，ZHANG Tumor 1．DepartmentofMedicalOncology，JiangsuHospital，Nanjing210009，China；2．Depart- meritMedical Tumor of Oncozogy，NanjingHospital evaluated and of with To the Docetaxelcombinedlow-dose Abstract：Objective efficacytoxicity Cisplatin asalternative for withadvancednonsmalleell cancer(NSCLC)． chemotherapyelderlypatients lung Methods wereenrolledinthe wastr∞tedas Thirty-one patients study．Each following：DoeetaxeI infusion weekfor 40mg／m2 once tWO infusionon 2con- per weeks；Cisplatin14rng／rn2／d dayl～5．After secutivetreatmentcourse，eachfor4weeks，evaluationoftheshort-termandadverseeffectswas efficacy carriedout．Resultsoverall rateWaS The resporme 32．3％(10／31)．CRO(0％)，PRl0(32．3％)，SDl6 (51．6％)，PD5(16．1％)，medianOSwas10．3 toxicities，whichweremild，in- months．Hematologic eluded in wasWeakness grade 29．0％(9131)．Themajor toxicity m～Ⅳneutropenia non-hematologic (45．2％)。ConelmionDocetaxelcombinedwithlow-dose asalternative Weekly Cisplatin chemotherapy is for