血液系统疾病的食疗课件.pptVIP

Agents Used in Thrombus Heparin IV Injection Indications of Heparin Adverse reactions of Heparin Bleeding Heparin-induced Thrombocytopenia Coumarins Dicoumarol Warfarin Acenocoumarol Target- Vitamin K epoxide reductase Inhibition of Prothrombin VII, IX, X Protein C and S 1. Relationship between Dosage and Speed of Onset? 2. The only differnece among oral coumarins in producing and maintaining hypoprothrombinemia is? Toxicity of Coumarins Hemorrhagic Disorder in the Fetus. Birth defect of abnormal bone formation Hemorrhgaic infarction during the first weeks of therapy Antiplatelet Drugs ADP-Adenosine Diphosphate,to induce platelet aggregation TXA2-Thromboxane A2, platelet activation and vassolconstriction 5-HT-Serotonin Aspirin—low dase, irreversible inhibition of TXA2, Ridogrel—strong inhibition of TXA2 Persantin—vasodilator,in combination with aspirin Clopidogrel and Ticlopidine-- Fibrinolytic Drugs Anistreplase Classification: Thrombolytic enzyme Action/Kinetics: Prepared by acylating human plasma derived from lys-plasminogen and purified streptokinase derived from group C beta-hemolytic streptococci. When prepared, anistreplase is an inactive derivative of a fibrinolytic enzyme although the compound can still bind to fibrin. Anistreplase is activated by deacylation and subsequent release of the anisoyl group in the blood stream. The production of plasmin from plasminogen occurs in both the blood stream and the thrombus leading to thrombolysis. Lyses thrombi obstructing coronary arteries and reduces the size of infarcts. t1/2: 70-120 min. Bleeding Drugs: Vitamin K Thrombin Adrenocorticosteroids 29 Glucocorticoid Excess: Cushing’s syndrome 2. Glucocorticoid Deficiency 3. Mineralocorticoid Excess: Primary Aldosteronism Addisons disease A disease caused by partial or total failure of adrenocortical function, which is characterized by a bronzelike pigmentation of the skin and mucous membranes, anemia, weakness, and low blood pressure