北京地区流行性脑脊髓膜炎的临床及实验研究_临床医学论文.docVIP

北京地区流行性脑脊髓膜炎的临床及实验研究_临床医学论文 北京地区流行性脑脊髓膜炎的临床及实验研究_临床医学论文 作者:蒋荣猛 李蔚莉 李兴旺 丁静秋 【摘要】 目的 探讨北京地区2002年与2001年流行性脑脊髓膜炎在临床及实验室检查等方面的差异。方法 整群抽取北京地坛医院2001.1.1—2001.5.30住院治疗的全部流脑病例39例，及2002.1.1—2002.5.30住院治疗的全部流脑病例50例，分成两组。对这2组病例的流行病学、临床表现、实验室检查进行描述性比较分析。结果 2002年组流行性脑脊髓膜炎暴发型病例、死亡病例、并发呼吸衰竭病例、发生低钾血症、低钠血症、低氯血症、肾功能及心肌损害的病例均明显高于2001年组（0.05）；肝功能损害两组无明显差异（Pgt;0.05）；2002年组病例的脑膜炎双球菌阳性率较2001年组低（0.01）。结论 2002年组病例死亡率较2001年组高与2002年组暴发型病例多有关；2002年组病例多器官功能损害多，提示脑膜炎双球菌泛嗜性感染的可能；2002年组病例的脑膜炎双球菌阳性率较低，可能与2002年细菌型别变迁有关。 【关键词】 流行性脑脊髓膜炎；多脏器功能损害；脑膜炎双球菌 【Abstract】 Objective To elucidate the differences of the clinical symptoms and laboratory tests of epidemic cerebrospinal meningitis between in 2001 and 2002 in Peking region. Methods Whole aspiration 39 cases of 2001.1.1-2001.5.30 hospitalization case of all epidemic cerebrospinal meningitis that treated in Peking Ditan hospital, and 50 cases of 2002.1.1-2002.5.30 hospitalization case of all epidemic cerebrospinal meningitis that treated in Peking Ditan hospital, and be divided into two groups. To describe compare analysis the epidemiology, clinical performance, the check of laboratory of this 2 groups. Results The fulminant type case and mortality rate of the 2002s group were higher than the 2001s group( 0.05);In the 2002s group occurrence rate for hypopotassemia, hyponatremia, hypochloraemia were significant deference than the 2001s group ( 0.05);In the 2002s group the lesion in the kidney function and myocardium were significant deference than the 2001s group( 0.05);The cases that have respiratory failure in the 2002s group increased than the 2001s group(0.05), but the lesion in the liver function have no significant difference in the two groups (Pgt;0.05); The positive rate of meningitis diplococcus in the 2002s group was lower than the 2001s group ( 0.01). Conclusion The higher mortality rate was relate to the large percentage of the fulminant type cases in the 2002s group. Multiple organ function lesion is a significant characteristic in the 2002