哌拉西林舒巴坦钠与苄星青霉素联合治疗一、二期梅毒的疗效及不良反应评价_临床医学论文.docVIP

哌拉西林舒巴坦钠与苄星青霉素联合治疗一、二期梅毒的疗效及不良反应评价_临床医学论文 哌拉西林舒巴坦钠与苄星青霉素联合治疗一、二期梅毒的疗效及不良反应评价_临床医学论文 【摘要】 目的 评价哌拉西林舒巴坦钠与苄星青霉素联合治疗一、二期梅毒患者的疗效及不良反应。方法 回顾性分析我院2008年12月～2009年10月收治的72例一、二期梅毒患者的临床资料，所有患者随机分为治疗组和对照组各36例，治疗组采用哌拉西林舒巴坦钠与苄星青霉素联合治疗，对照组仅采用苄星青霉素治疗，比较分析两组患者的临床疗效及不良反应发生情况。结果 治疗组的痊愈率为83.3%，明显高于对照组的61.1%，两组间有显著性差异(0.05);治疗组的不良反应发生率为8.3%，略低于对照组的13.9%，两组间无显著性差异(Pgt;0.05)。结论 哌拉西林舒巴坦钠与苄星青霉素联合治疗一、二期梅毒患者获得较佳疗效，且不良反应少，值得临床推广应用。 【关键词】 梅毒;早期;哌拉西林舒巴坦钠;苄星青霉素;疗效;不良反应 Abstract Objective To evaluate the curative effect and side effect of the combined treatment with piperacillin sulbactam sodium and benzathine penicillin on primary and secondary syphilis.Methods A retrospective analysis was made to the clinical data of 72 cases with primary or secondary syphilis; they were randomly divided into 2 groups: treatment group and control group, 36 cases in each; the combined treatment with piperacillin sulbactam sodium and benzathine penicillin was given to patients in treatment group while only benzathine penicillin was given to patients in control group; a comparative study was made to the curative effects and side effects between the 2 groups. Result The curative rate of treatment group was 83.3%, much higher than that of control group (61.1%), the difference between the 2 groups was significant (0.05); the occurrence of side effect of treatment group was 8.3%, a little lower than that of control group (13.9%), the difference between the 2 groups was of no significance (0.05). Conclusions The combined treatment with piperacillin sulbactam sodium and benzathine penicillin is of better curative effect and less side effect on primary and secondary syphilis; it is worthy of wide application in clinic. 　　KEYWORDS syphilis primary piperacillin sulbactam sodium benzathine penicillin 　　curative effect side effect 　　梅毒是由苍白螺旋体引起，主要的传播途径为性传播和胎传，其特异性抗体的检出是临床诊断的主要依据。一期梅毒和二期梅毒都属于早期梅毒。一期梅毒通常可能先出现流行性感冒一样的全身症状，随后会有全身淋巴结的肿大及皮肤粘膜的多种损害。二期梅毒疹表面梅毒螺旋体很多，因此传染性也最强。本研究回顾性分析我院收治的72例一、二期梅毒患者，分别采用哌拉西林舒巴坦钠与苄星青霉素联合治疗及单独苄星青霉素治疗，旨在评