基于DRSP的经前期综合征肝气逆证疗效评价参考标准的建立_临床医学论文.docVIP

基于DRSP的经前期综合征肝气逆证疗效评价参考标准的建立_临床医学论文 基于DRSP的经前期综合征肝气逆证疗效评价参考标准的建立_临床医学论文 作者：祝玉慧,王海军,乔明琦,张惠云 【摘要】 目的 针对目前临床缺乏经前期综合征(PMS)肝气逆证疗效评价标准的现状,建立PMS肝气逆证疗效评价参考标准。方法 采用随机双盲对照多中心的方法,将356例PMS肝气逆证患者随机分为2组,一组为经前平组,另一组为安慰剂组,随访调查连续3个月经周期。第1、2个月经周期在随访观测的同时应用经前平颗粒、安慰剂,在治疗阶段处于“治疗中”,第3个月经周期停止用药,继续随访观察,处于“治疗后”观察阶段。以前期研究阶段中2个月经周期所收集的数据为“治疗前”阶段。利用症状严重程度每日记录量表(DRSP),初步建立PMS肝气逆证疗效评价标准。结果 经前平颗粒和安慰剂对于PMS肝气逆证患者均具有治疗效果,经前平组疗效明显优于安慰剂组；DRSP可以作为疗效评价指标。结论 初步建立了PMS肝气逆证疗效评价参考标准,为PMS肝气逆证疗效评价行业标准的建立提供了重要工作基础。 【关键词】 经前期综合征；肝气逆证；疗效评价；经前平颗粒 Abstract：Objective Aimed at the problem that there is no curative effect standard of liver-qi invasion of premenstrual syndrome (PMS), to construct the reference standard of curative effect evaluation for the liver-qi invasion of PMS. Method Curative effect evaluation research of Jingqianping granule was designed by the principle of random, double blind, contrast and multicentre. Three hundred and fifty-six patients with liver-qi invasion of PMS were divided into two groups randomly, one was Jingqianping granule, the other was placebo. Patients were given Jingqianping granule and placebo respectively for two menstrual cycles and followed–up for three menstrual cycles. The reference standard of curative effect evaluation for the liver-qi invasion of PMS was constructed with daily rating of severity of problems form (DRSP). Result Jingqianping granule and placebo have therapeutic effect on the patients with liver-qi invasion of PMS, and Jingqianping granule was better than placebo. DRSP can be used as indexes of curative effect evaluation. Conclusion The initial establishment of the curative effect evaluation criterion of PMS liver-qi invasion provides the important foundation for profession criterion’s establishment. 　　Key words：premenstrual syndrome；liver-qi invasion syndrome；curative effect evaluation；Jingqianping granule 现代流行病学研究表明,国外育龄期妇女经前期综合征(PMS)现患率为20%～40%,其中2%～10%的患者日常生活受到严重影响[1-2]；国内现患率为41.9%[3]。国外已有报道,PMS患者临床表现出不同症状类型,并且根据其情绪行为、躯体症状等特征进行分类,同时针对不同亚型选择不同药物具有较好