低剂量5-FU持续输注联合每周L-OHP治疗晚期胃肠道肿瘤.pdfVIP

低剂量 5 FU 持续输注联合每周 L OHP 治疗晚期胃 肠道肿瘤 江苏省宜兴市人民医院肿瘤科 214200 吴勤芳 邓建良 鲁治文 汤月华 摘要 目的 观察低剂量5-氟脲嘧啶(5-FU)持续输注联合每周草酸铂 L 2 OHP 方案治疗晚期消化道恶性肿瘤的疗效 方法 5-FU250mg/m /d 持续深静 2 脉输注3周 L-OHP 85mg/m /d 静脉输注2小时 每周1次 连用3周 以上 方案连用二周期为一疗程 化疗后休息1个月评定疗效 结果 全组26例 总 有效率为46 15% 18例晚期大肠癌有效率为38 89 8例晚期胃腺癌有效 率为62 50% 中位缓解期4.5个月(2 6个月) 没有 毒副反应发 生 结论 认为低剂量5-FU持续输注联合每周草酸铂 L OHP 方案治疗晚期 消化道恶肿瘤是一个有效低毒的化疗方案 关键词 晚期消化道恶性肿瘤 低剂量5-氟脲嘧啶/每周草酸铂 化疗 Combined Chemotherapy of Continuous Infusion of Low-dose of 5-Fluorouracil and weekly Oxaliplatin in Advanced or Recurrent Gastrointestinal Carcinoma Wu Qingfang,Deng Jianlian Department of Oncology, Yixing Peoples Hospital of JiangSu, Yixing(2144200) Abstract Objectives:To evaluate the efficacy and toxicity of the continuous central venous infusion (c.c.v.i) of low-dose of 5- fluorouracil with weekly Oxaliplatin. Methods: Twenty-six patients with advanced or recurrent gastrointestinal carcinoma(18 in colon,8 in stomach)were observed in this study.5-Fu was given with a dosage of 250mg/m2/d.c.c.v.i.for 3 weeks,and L-OHP with a dosage of 85mg 2 /m /d.infused in two hour,one times a week, and lasted for 3 weeks. Two treating courses were carried out with a pne month interval in between. Results: The overall response rate was 46 15%(12/26), including 12 cases of partial responses. The response rates of colonic and gastric cancers were 38 89 (7/18)and 62