脑缺血大鼠的炎症反应与神经元坏死.docVIP

脑缺血大鼠的炎症反应与神经元坏死 大脑中动脉闭塞模拟的脑缺血大鼠模型中炎症反应主要发生于梗死区及其周围区域，且在损伤区域中神经元常出现坏死和凋亡，而小胶质细胞数量增加且被活化。来自中国南昌大学医学院吴晓牧博士所带领的团队，观察到在大脑中动脉闭塞后12h脑缺血区域出现神经元凋亡，4-6d时达到峰值，炎症因子和小神经胶质细胞参与大脑中动脉闭塞损伤及修复过程，细胞间黏附分子1的表达与血脑屏障通透性呈正相关。提示细胞间黏附分子1可能参与破坏血脑屏障，激活小胶质细胞，对大脑细胞凋亡产生影响。这些结局可成为修复、保护损伤神经元的靶标，抑制其过程可产生保护损伤神经元的效应。相关文献发表于《中国神经再生研究（英文版）》杂志2014年10月第19期。 免疫组化染色显示，大脑中动脉闭塞12h后大鼠脑组织中小胶质细胞特异性蛋白Iba-1表达阳性的细胞 Article: Infammatory response and neuronal necrosis in rats with cerebral ischemia, by Lingfeng Wu1,2, Kunnan Zhang1, Guozhu Hu3, Haiyu Yang3, Chen Xie3, Xiaomu Wu1 (1 Nanchang University Medical College, Nanchang, Jiangxi Province, China; 2 Department of Neurology, People’s Hospital of Jiangxi Province, Nanchang, Jiangxi Province, China; 3 Institution of Neurology, People’s Hospital of Jiangxi Province, Nanchang, Jiangxi Province, China) Wu LF, Zhang KN, Hu GZ, Yang HY, Xie C, Wu XM. Inflammatory response and neuronal necrosis in rats with cerebral ischemia. Neural Regen Res. 2014;9(19):1753-1762. 欲获更多资讯：Neural Regen Res Inflammatory response and neuronal necrosis in rats with cerebral ischemia In the middle cerebral artery occlusion (MCAO) model of ischemic injury, inflammation primarily occurs in the infarct and peripheral zones. In the ischemic zone, neurons undergo necrosis and apoptosis, and a large number of reactive microglia are present. Prof. Xiaomu Wu at Nanchang University Medical College, China and colleagues found that neuronal necrosis appeared at 12 hours after MCAO and peaked at 4 to 6 days after MCAO; inflammatory cytokines and microglia played a role in damage and repair after MCAO; serum intercellular cell adhesion molecule-1 levels were positively correlated with the permeability of the blood-brain barrier. These findings indicate that intercellular cell adhesion molecule-1 may be involved in blood-brain barrier injury, microglial activation, and neuronal apoptosis. Inhibiting blood-brain barrier leakage may alleviate neuronal injury following ischemia. The relevant study has bee