黄连活性成分的作用及机制研究进展_李彩虹.pdfVIP

2010 21 2 LIS IZ EN MEDICINE AND MATERIA M EDICA RESEARC 2010VOL. 21NO. 2 1, 2 1* 李彩虹 , 周克元 ( 1., 523808; 2., 524023) :黄连及其活性成分特别是小檗碱在体外细胞研究中具有广泛的药理活性, 文章综述了近年来在抗肿瘤抗糖尿病 抗菌抗炎神经调节等几大方面作用及机制研究进展, 经过分析整理表明: 进一步筛选小檗碱以外的黄连活性有效部位 及如何提高小檗碱的生物利用度来充分 挥小檗碱的疗效将是今后黄连研究的重点 :黄连; 活性成分; 作用机制 : R285. 5 : A : 1008-0805(2010)02-0466-03 S tudy Advances on the E ffects andM echan ism s ofA ctive C on stituen ts of Cop tid is R h izom a 1, 2 1* LI Ca-ihong , Z OU K e-yuan ( 1. Institute of B iochem istry and M olecular B io logy, Guangdong M ed ical College, Dongg uan 523808, China; 2. GuangdongK ey Laboratoryf orR esearch and D e elopment of N aturalD rug s, Zhanj iang Guangdong, D ongguan 523808China ) Abs tract: Cop tidisRh izoma and its active compounds especially berberinehave awide range ofpharmacologicalactivities in itro cell study. This review summarizes severalmajor effects including anti- tumor, anti- diabetes, antibacteria and anti- inflammato- ry activities and neurological regulation of the constituents in CoptidisRhizoma and itsmechanisms. A further screening of the ac- tive compounds ofCop tidis Rhizoma besides berberine and mi provement of the bioavailability of berberine in order to give full effect in treating patientsw ill be the focus of the study in the future. K ey w ord s: C op tidis rhizom a; A ctive ingrediens; M echanisms Cop tid is rhiz om a, , , , ( 4% ~ 8% ), 1 ( berberine)( coptisine), (worenine) ( palmatine)( jatrorrhizine) ( epiberberine) (mognoflorine), 9