双黄连治疗小儿肺炎有效性与安全性的meta分析.pdfVIP

双黄连治疗小儿肺炎有效性和安全性的meta 分析 张海英，任晓蕾，李玉珍(北京大学人民医院药剂科,北京100044) 【摘要】目的：系统评价注射用双黄连单独应用治疗小儿肺炎的有效性和安全性。方法：计 算机检索Medline ，Embase ，Cochrane 图书馆临床对照试验资料库，CBMdisc，CNKI及万方 数据库，纳入比较注射用双黄连单独应用治疗小儿肺炎的随机对照试验，对纳入研究的方法 学质量进行评价, 并应用RevMan5.0软件进行统计分析。结果：共纳入15个随机对照试验 （RCT ）。Meta-分析结果表明，对小儿肺炎，单独应用注射用双黄连的疗效好于单独应用抗 感染药物，且对于退热时间、咳嗽缓解时间、肺部啰音吸收时间、胸片X线炎症吸收时间等 指标，两组比较，差异具有统计学意义。未报道注射用双黄连临床应用相关的严重不良反应。 结论：现有临床证据表明，注射用双黄连单独应用对于小儿肺炎的疗效好于单独应用抗感染 药物。在缩短患者发热时间、咳嗽症状、肺部啰音吸收时间、胸部X线炎症吸收时间上明显 好于抗感染药物，且未见明显不良反应。但由于纳入研究质量所限,降低了该系统评价结论 的可靠性。尚需要开展更多设计合理、执行严格、多中心大样本的随机对照试验以进行进一 步证实。 【关键词】：双黄连；抗感染药物；小儿肺炎；meta 分析 Meta- analysis of efficacy and security of shuanghuanglian for children pneumonia ZHANG Haiying ，REN Xiaolei ， LI Yuzhen (Department of Pharmacy, People′s Hospital, Peking University, Beijing 100044) 【abstract 】Objective：To systematically evaluate the efficacy and security of shuanghuanglian alone for children pneumonia. Methods ：We searched Medline, Embase, The Cochrane Library, CBMdisc and CNKI. The quality of included studies such as randomization, blinding and allocation concealment was evaluated and meta-analysis was performed by RevMan5.0 software. Results ：Fifteen randomized controlled trials (RCTs) were included. As shuanghuanglian group ( shuanghuanglian injection or powder for injection plus basic therapy ) was compared with anti infective group ( antibiotics plus basic therapy) , the meta-analysis indicated that the total clinical cure rate of shuanghuanglian group was better than that of anti infectiv group. But there were statistical difference in defervescence time, cough relieving time, the absorption time of lung rale and the absorption time of chest X-ray shadow between shuanghuanglian group and anti infective group. Serious adverse reactions had not been reported in the trials. Conclusions：According to the Meta-analysis’s result, shuanghuanglian was effective and safe for treating child pneumonia. Especially, shuanghuang