果蝇体系中内噪音维持的生理振荡.pdfVIP

郎秀峰等 No.: 0927 果蝇体系中内噪音维持的生理振荡 郎秀峰 1,* ，李前树 2 1 北京航空航天大学理学院，北京 100083 2 北京理工大学理学院，北京 100081 摘要 生命体内生理节奏主要是由分子水平上的基因表达来调节的，这个过程具有内在的随机性。本文采用一个简化果蝇模型来 研究这种随机性对于生理节奏过程的影响。这个模型建立在含时间延迟的正负两种反馈基础上。研究发现：对于模型参数的一些 值，确定性体系始终处于一个稳定定态，但在随机体系中，内噪音能够维持一种周期接近24小时的振荡。这种振荡的振幅随着内 噪音强度的变化发生很大改变，而周期基本保持不变。在特定的噪音强度下这种振荡展现出最好的相干性，即出现了内在的相干 共振。此外，研究证实了正反馈中的时间延迟能够有效地调节噪音维持生理振荡的性能。 关键词 生理节奏，内噪音，相干共振 Internal Noise-Sustained Circadian Rhythms in a Drosophila Model 1 2 Lang Xiu-feng , Li Qian-shu 1School of Science, Beijing University of Aeronautics and Astronautics, Beijing 100083, China 2School of Science, Beijing Institute of Technology, Beijing 100081, China Abstract Circadian rhythms in the living systems, mainly regulated by gene expression at the molecular level, have inherent stochasticity. In this paper, we use a reduced Drosophila model, which incorporates negative and positive feedback loops, each with a time delay. It is found that internal noise sustains reliable oscillations, close to 24h, in a region of parameter space, where the deterministic kinetics would evolve to a stable steady state. The amplitudes of noise-sustained oscillations are significantly affected by the variation of internal noise level, while the period hardly changes. The maximal coherence of the oscillations could be found at some noise intensity, indicating the occurrence of intrinsic coherence resonance. In addition, it is also found that time delay in the positive feedback could efficiently tune the performance of the noise-sustained oscillations. Key words Circadian rhythms, Internal noise, coherence resonance 1 引言