关于针刺穴位效应启动初始调控机制探讨.pdfVIP

·512· Shanghai J Acu-mox, Jun 2013, Vol 32, No 6 文章编号:1005-0957(2013)06-0512-03 ·述 评· 关于针刺穴位效应启动的初始调控机制的探讨 赵雪,陈波,郭义 (天津中医药大学实验针灸学研究中心,天津 300193) 【摘要】 多年研究表明,针刺可引起穴位微环境中的神经、肥大细胞和一些化学物质应答。作者认为,针刺后穴位局部微环 境中的神经-肥大细胞-相关化学物质相互作用,相互影响,构成了针效启动网络中的关键环节和调控因素,使针刺信号得以启 动并级联放大,进而发挥整体调节作用。根据这一假说,在针刺穴位治疗脏腑疾病的实验研究平台上,系统研究穴位处的神经- 肥大细胞-相关化学物质的相互关系及其在针效启动中的作用,可望在针刺作用原理研究方面取得实质性进展。 【关键词】 针刺;穴位研究;针灸效应 【中图分类号】 R2-03 【文献标志码】 A DOI:10.3969/j.issn.1005-0957.2013.06.512 Investigation of Early Modulatory Mechanisms in Initiating the Effect of Acupuncture on Points ZHAO Xue, CHEN Bo, GUO Yi. Tianjin University of Traditional Chinese Medicine School of Acupuncture-moxibustion,Tianjin 300193,China [Abstract] Many years’ studies have shown that acupuncture can induce the responses of nerves, mastocytes and chemical substances in acuppoint micro-circumstances. The authors consider that nerves, mastocytes and chemical substances in local acuppoint micro-circumstances interact after acupuncture to form key links and modulating factors in the network of acupuncture effect triggering, which trigger and successively amplify an acupuncture signal to produce a whole regulating effect. Based on this hypothesis, a systematic study of the interrelationship between nerves, mastocytes and chemical substances in the acupoint and their actions in initiating an acupuncture effect in an experimental research on acupuncture treatment for visceral diseases may make a substantial advance in studying acupuncture mechanisms of action. [Key words] Acupuncture; Acupoint research; Acupuncture effect 穴位是针刺刺激的初始应答部位,可以感受针刺 研究表明,穴位区传入神经末梢密度远比非穴位区高, 的物理刺激并将其转化为可被机体识别的生物学信息, 其中临床常用穴位区神经末梢最为密集,神经末梢密 穴位局部微环境的变化在信息转换中发挥着重要作 集带沿着经脉的走向分布,证实“穴位”是神经支配密 用。基于多年研