1药物洗脱支架载药涂层的的研究进展.pdfVIP

药学学报 Acta Pharmaceutica Sinica 2011, 46 (11): 1301− 1307 ·1301 · 药物洗脱支架载药涂层研究进展 * 陈文平, 詹红兵 (福州大学材料科学与工程学院, 福建 福州 350108) 摘要: 药物洗脱支架自 2002 年在欧洲面世以来极大地改变了心血管介入术, 与裸支架单一的机械支撑作用 相比, 药物洗脱支架在病灶处释放的药物能显著地降低再狭窄率。支架表面涂层作为一种重要药物靶向输送载 体, 能够最大程度地降低药物对系统的毒副作用, 同时在药物的控制释放方面发挥重要的调节作用。涂层材料 和制备技术不仅影响支架表面的生物相容性和支架植入过程的表面完整性, 也决定了药物的输送传递方式和释 放速率。本文介绍了血管载药支架作为临床治疗器械类产品的结构、技术、应用现状及具体面临的问题, 在此 基础上, 分析提炼了相关涂层设计原则, 阐述了近年来涂层材料和覆膜技术的研究进展, 并展望了该领域的发展 前景。 关键词: 支架; 药物载体; 药物导向; 药物释放系统; 狭窄 中图分类号: R943 文献标识码: A 文章编号: 0513-4870 (2011) 11-1301-07 Recent developments of drug eluting stent coatings * CHEN Wen-ping, ZHAN Hong-bing (College of Materials Science and Engineering, Fuzhou University, Fuzhou 350108, China) Abstract : Drug eluting stents (DESs) have revolutionized the interventional cardiology over the past decade since the first DES became commercially available in Europe in 2002. Compared to bare metal stents that are deployed to keep the vessel open by mechanical force, DESs have an additional function of reducing restenosis by the action of the drug on the target site. Coatings on the stent surface which ensure the maximum delivery of therapeutic agents to the target site with minimal systematic toxicity, also play an important role in adjusting the drug release profile. Coating material and technology not only affect the surface biocompatibility and the integrity maintenance during the i