TRAIL抗癌作用分子机制.pdfVIP

TRAIL 抗癌作用的分子机制 韩丽辉 综述 ,孙汶生 审校 ( 山东大学医学院微生物与免疫学教研室, 山东 济南 250012) 摘 要 : TRAIL 是近年新发现的一种凋亡诱导配体 , 它能够选择性地诱导肿瘤细胞凋亡 , 而使正常细胞逃逸其杀伤作用。TRAIL 强大的凋亡诱导能力和选择性的杀伤作用 , 引起了广大研究者极大的兴趣。本文从 TRAIL 的结构功能开始分析, 论述了 TRAIL 作用 的分子机制,为广大医务工作者进一步深入研究和开发 TRAIL 这一新型抗癌分子奠定基础。 关键词 : TRAIL ;肿瘤 ;凋亡 ( ) 中图分类号:R730. 51 文献标识码 :A 文章编号 :1671 - 170X 2002 02 - 0111 - 04 The Mechanisms of a New T e Antitumor Molecule ———TRAIL yp HAN Lihui ,SUN Wenshen ( De t. o Microbiolo and Immunolo , School o Medicine , Shandon Universit , Jinan 250012 , China) g p f gy gy f g y ( ) Abstract :TRAIL TNF related a o tosis inducin li and is a newl identified a o tosis inducin li and. It could selectivel induce the a o tosis p p g g y p p g g y p p of tumor cells but s are the normal tissue cells. Its owerful ca abilit of inducin a o tosis and its s ecial selectivit of killin tumor cells have raised p p p y g p p p y g the interests of many researchers. Many of researchers have done a lot to find out the mechanism. In this article , we will introduce the general molecular mechanisms of the antitumor molecule named TRAIL , which will establish a sound foundation for a further research of TRAIL and for the further application of it in the future. Ke words : TRAIL ;neo lasms ;a o tosis y p p p TRAIL ( TNF related a o tosis inducin li and ,肿瘤 功能也在不同的实验室中分别得到了验证。 p p g g