粪菌移植：老故事和新未来.pdfVIP

·专家述评· DOI:10.13276/j.issn.1674-8913.2015.01.002 粪菌移植：老故事与新未来 张发明，李 潘，崔伯塔，彭炤源，季国忠 （南京医科大学：第二附属医院消化医学中心，消化内镜研究所，江苏 南京 210011） Fecal microbiota transplantation: old story, new future ZHANG Fa-Ming, LI Pan, CUI Bo-Ta, PENG Zhao-Yuan, JI Guo-Zhong Institute of Digestive Endoscopy, Medical Center for Digestive Diseases, Second Affiliated Hospital, Nanjing Medical University, Nanjing 210011, China Abstract Fecal microbiota transplantation (FMT) is an old therapy with at least 1 700 years in the world medical 【 】 history. However, FMT has gained great development only in the recent years. The recent studies demonstrated that FMT has great clinical value on the treatment of Clostridium difficile infection, inflammatory bowel disease and other diseases. The present article reviewed the history and terminology of FMT, and discussed its standardization, indications and some factors limiting the development of the therapy. Keywords fecal microbiota transplantation; gut microbiota; microecology; inflammatory bowel disease 【 】 【摘 要】 粪菌移植（FMT）作为一种古老的治疗手段，在人类医学史上至少已有1 700年。近年来，FMT得到 迅速发展，并显示出对难辨梭状芽孢杆菌感染、炎症性肠病等多种疾病的重要治疗价值。本文就FMT的医学史、 FMT的科学术语、FMT的标准化、适应证等内容进行讨论。 【关键词】 粪菌移植；肠道菌群；微生态学；炎症性肠病 【中图号】R516 【文献标识码】 A 粪菌移植（fecal microbiota transplantation，FMT） 酵的粪水或者从粪中分离的微生物群治病[3-13] 。FMT 的概念就是从健康人粪便中分离功能菌群，然 的演进呈非直线前进，它源于中国古代，近年在西方 后移植到患者消化道，通过重建患者肠道菌群而实 得到快速发展，欧美的医生比中国的医生