积雪苷霜和糠酸莫米松软膏联用治疗神经性皮炎疗效和安全性评价.pdfVIP

· 论 文 · 积雪苷霜和糠酸莫米松软膏联用治疗神经性皮炎疗效和安全性评价 向茯芝，余银霞，杜凌波，朱瑞政 (上海市瑞金医院集团闵行区中心医院皮肤科，上海 201100) 摘要： 目的 探讨积雪苷霜和糠酸莫米松软膏联用治疗神经性皮炎的疗效和安全性。方法 95例神经性皮炎患者随机分为 治疗组 ( 53)和对照组 (n=42)，治疗组以积雪苷霜联合糠酸莫米松软膏涂搽患处，一日1次，对照组单用糠酸莫米松软膏， 一 日1次，疗程共 3周，比较两组总有效率和不 良反应发生率。结果 治疗组与对照组总有效率分别为 86．79％和 88．10％， 囝 组间差异无统计学意义 (尸O．O5)；两组不 良反应发生率分别为 1．89％和 19．05％，组间差异显著 (尸0．01)。结论 积 雪苷霜和糠酸莫米松软膏联合用于治疗神经性皮炎安全且有效。 誉 = 关键词：积雪苷霜；糠酸莫米松；神经性皮炎 中图分类号：R986；R758．32 文献标志码：A 文章编号：1672—9188(2011)03—0156—03 9 Clinicalefficacyandsafetyofcentellatriterpenescream combiningwith momestasonefuroateointmentforneurodermatitis XIANGFu—zhi，YUYin—xia，DU Ling—bo，ZHU Rui-zheng (DepartmentofDermatology,MinhangDistrictCentralHospitalofShanghaiRujiinHospi~lGroup．Shanghai201100,China) Abstract：ObjectiveToobservetheclinicalefficacyandsafetyofcentellatriterpenescream combiningwith momestasonefuroateointmentforneurodermatitis．M ethodsNinety—fivecasesofneurodermatitiswererandomlydivided intotreatmentgroup (F=／53)andcontrolgroup (n=42)．Patientsintreatmentgroupwereadministeredwithcentella triterpenescream combiningwithmomestasonefuroateointmentoncedaily,whilepatientsincontrolgroupwereonly administeredwithmomestasonefuroateointment．Thecourseoftreatmentwas3weeks．Theratesofeffectivenessand adversereactionsintwogroupswerecompared．ResultsTheratesofeffectivenessintreatmentgroupandcontrolgroup were86．79％ and88．10％．Therewasnosignificantdifferencebetweentwogroups(PO．05)．Theincidenceofadverse reactionsintwogroupswere1．89％ and19．05％．Therewassignificantdifferencebetweentwogroups(尸0．01)． ConclusionCentellatriterpenescream combiningwithmomestasonefuroateointme