α-突触核蛋白的生物学功能及其在帕金森病中的作用.pdfVIP

中国病理生理杂志 ChineseJournalofPathophysiology 2010，26(9)：1855—1858 [文章编号】 1000—4718(2010)o9—1855—04 · 综 述 · 0【一突触核蛋 白的生物学功能及其在 帕金森病中的作用术 熊中奎 ， 胡雅儿 (绍兴文理学院医学院临床医学部 ，浙江 绍兴223000；上海交通大学医学院细胞调控实验室，上海 200025) Biologicalfunctionsof仅一synucleinanditsroleinParkinson’Sdisease XIONG Zhong—kui一 ．HU Ya—er2△ (DepartmentofClinicalMedicine，ShaoxingUniversityMedicalCollege，Shaoxing223000，China； ResearchLaboratoryofCellRegulation，ShanghaiJiaotongUniversitySchoolofMedciine， Shanghai200025，China．E—mail：yaerhu@shsmu．edu．cn) A【BSTRACT】 0t—Synucleinisidentifiedasaconstantcomponentofdopaminergicneuronalpaleeosinophilicin— clusions “theLewybodies”inParkinson’Sdisease．Infact，normal d—synucleinhaslotsofbiologicalfunctions，which regulatessynapticplasticity，integratespresynapticsignaling，regulatesdopaminelevelinthesynapse，modulatesmicroglial activationandlipidmetabolism ，andexertsheatshockprotein—likefunction．However，abnormalOt—synucleinleadsto pathological lesion．Mnaystudiesshow thatpathological —synucleinlevelsareelevatedundertheconditionofitsgene mutation，certainposttranslational modifications，dysfunctionofmolecularchaperonesorubiquitinproteasomesystem．The pathologicala—synucleinplaysanimportantroleinneurodegeneration，inparticular，Prakinson’Sdiseasebecauseitinter- ruptsintegrityofsynapticvesicles，ER—Golgitrafficandaxonal transport，inhibitshistoneacetylationandchaperone—me— diatedautophagy，stabilizesitselfagainstproteasomal dergadation，andleadstoneuroinflammationnadbanormalphospho— rylationoftau． [关键词] 一突触核蛋白；帕金森病 [KEYWORDS] 0t—synuclein；Parkinsondisease [中图分类号】 R363 [文献标识码] A doi：10．3969／j．issn．1000—4718．2010．09．039 仅一突触核蛋 白(—synucle