白藜芦醇与胡椒碱联用的抗抑郁作用可能涉及下丘脑5-HT系统及HPA+轴.pdfVIP

plants, having the effect of antioxidant，immune regulation，anti-ageing，and can prevent the neurodegenerative diseases. Piperine, a bioavailability enhancer, it could increase the activities of polyphenolic components when combined with them. In present study we assessed the antidepressant effects of combination of trans-resveratrol and piperine using the chronic unpredictable stress model of depression in rats and research their effects on the HPA axis. METHODS METHODS MMEETTHHOODDSS We subjected animals to the chronic stress protocol for 21 days with the