HIF-1α、VEGF在胰腺癌组织中的表达和临床意义.docVIP

HIF-1α、VEGF在胰腺癌组织中的表达及临床意义 作者：陈建峰 作者单位：（义乌市中心医院 肝胆外科，浙江 义乌 322000） 【摘要】 目的 研究胰腺腺癌组织中的低氧诱导因子-1Α(hypoxia-inducible factor-1Α，HIF-1Α)和血管内皮生长因子(vascular endothelial growth factor，VEGF)的表达情况及其临床意义。方法 采用Western blotting方法 检测30例胰腺腺癌组织及其中9例胰腺癌相应癌旁胰腺组织中HIF-1Α、VEGF的表达。结合临床病例资料，分析HIF-1Α、VEGF与肿瘤的大小、部位、病理分化程度、淋巴结转移及胰腺癌TNM分期之间的关系。结果 统计结果显示HIF-1Α、VEGF在胰腺癌肿瘤组织中的表达高于癌旁组织，两者比较具有统计学意义（P＜0.01），同时相关性分析显示肿瘤组织中HIF-1Α与VEGF两者之间具有正相关性（r＝0.655，P＜0.01）。结合临床资料分析，胰腺癌肿瘤组织中HIF-1Α、VEGF的表达与肿瘤大小、淋巴结转移和胰腺癌TNM分期密切相关，并且具有统计学意义（P＜0.01）。结论 胰腺癌组织中HIF-1Α、VEGF存在高表达，HIF-1Α、VEGF和肿瘤大小、淋巴结转移和胰腺癌TNM分期有关。HIF-1Α、VEGF可能可作为判断胰腺癌预后的一个指标。 【关键词】 胰腺肿瘤；低氧诱导因子-1Α；血管内皮生长因子 Expressions of HIF-1Α and VEGF in pancreatic cancer and their clinical significance CHEN Jianfeng. Department of General Surgery， Central Hospital of Yiwu， Zhejiang 322000 Abstract Objective To investigate the expressions of hypoxia-inducible factor-1 alpha (HIF-1Α) and vascular endothelial growth factor (VEGF) in pancreatic cancer and clinical significance. Methods The expressions of HIF-1Α and VEGF in 30 cases of pancreatic cancer and corresponding pancreatic para-cancer tissues (9 cases) were studied with Western blotting method. The relationship and clinical significance of HIF-1Α and VEGF expression in pancreatic cancer were analyzed with the clinical data. Results Expressions of HIF-1Α and VEGF in pancreatic cancer tissue were significantly higher than that in para-cancer tissue （P＜0.01）， and the correlative analysis revealed that the expression of HIF-1Α was positively correlated with VEGF （r＝0.655， P＜0.01）. The levels of HIF-1Α and VEGF were closely related with the size of tumor， the lymphnode metastasis and TNM stage. Conclusion Over-expressions of HIF-1Α and VEGF were found in pancreatic cancer. HIF-1Α and VEGF may play important roles in the carcinogenesis and aggression in pancreatic cancer. HIF-1Α and VEGF may be a useful marker for evaluating prognosis in pancreatic cancer.