骨髓间充质干细胞治疗骨关节炎：可能和未来.docVIP

骨髓间充质干细胞治疗骨关节炎：可能与未来 张平平，向?川 山西医科大学第二医院骨科实验室，山西省太原市?030001 Bone marrow mesenchymal stem cells for osteoarthritis: its possibility and future Zhang Ping-ping, Xiang Chuan Orthopedics Laboratory, Second Hospital of Shanxi Medical University, Taiyuan 030001, Shanxi Province, China 摘要? 背景：药物治疗骨关节炎不理想，近年来越来越多的研究在尝试采用干细胞移植治疗骨关节炎。 目的：综述分析干细胞治疗骨关节炎及其临床应用、和存在的障碍。 方法：由第一作者应用计算机检索PubMed、中国期刊全文数据库(CNKI) 1998年3月至2013年10月相关文献。在PubMed检索中输入英文单词“stem cell，Osteoarthritis，bone metabolism，bone marrow mesenchymal stem cells”之间以“AND”形式检索，在中国期刊全文数据库中输入主题词“干细胞，骨关节炎，骨代谢，骨髓间充质干细胞”之间以“并且”关系为检索词选择模糊查询进行检索。选择文章内容与干细胞治疗骨关节炎有关者，同一领域文献则选择近期发表在权威杂志文章。 结果与结论：初检得到79篇文献，选择了符合纳入标准的50篇文献进行综述。应用干细胞治疗骨关节炎，其治疗目的主要是通过促进软骨组织修复来达到，使用的方法是干细胞移植及诱导干细胞分化。干细胞可以治疗骨关节炎，具有广阔应用前景。 中国组织工程研究杂志出版内容重点：干细胞；骨髓干细胞；造血干细胞；脂肪干细胞；肿瘤干细胞；胚胎干细胞；脐带脐血干细胞；干细胞诱导；干细胞分化；组织工程 全文链接： 关键词?：?干细胞；?骨髓干细胞；?骨髓间充质干细胞；?骨关节炎；?骨代谢；?细胞治疗；?软骨组织修复； ?? Abstract： BACKGROUND:?Nowadays treatment of osteoarthritis with drugs is not ideal. In recent years, more and more scientists try to use stem cells to treat osteoarthritis. OBJECTIVE:?To explore the stem cell treatment for osteoarthritis in order to promote its clinical application and find out its difficulties. METHODS:?A computer-based online search of PubMed database and CNKI database between March 1998 and October 2013 was performed to search related articles with the key words of “stem cell, osteoarthritis, bone metabolism, bone marrow mesenchymal stem cells” in English or in Chinese, respectively. The word “AND” was used for the connection between the word retrieval. Literatures related to stem cells treatment for osteoarthritis were selected; in the same field, the articles published lately in authoritative journals were preferred. RESULTS AND CONCLUSION:?A total of 79 literatures were primarily selected, and 50 documents were involved for summary according to inclusion criteria. The stem cell treatment for osteoarthritis is realized mainly by promoting the repair of cartilage tissue. Com