大鼠单次与多次给予PAC-1的药物动力学的研究.pdfVIP

大鼠单次和多次给予PAC．1的药物动力学研究 房丽娜，陈晓辉，王刚，赵旭，宋真，任磊，毕开顺’(沈阳药科大学．沈阳110015) 摘要：目的讨论健康大鼠单次和多次给予PAC．1的药物动力学特点．方法健康大鼠分别单次和多次灌胃给予PAC·l， 给药剂量60 对主要药动学参数进行统计学处理。结果单次灌胃给予PAc．1后雄性大鼠和雌性大鼠的主要药动学参数：T。。分别为 0．05)，PAC．1在大鼠体内不易蓄积． 关键词：PAC．1：单次给药：多次给药；药物动力学 PharmacokineticofPAC-1after and inrats study singlemultipledosing FANGLi．ha,CHEN Xu，SONG Xiao．hui，WANGGang，ZHAO Zhen，RENLei，BI 10015) pharmaceuticaluniversiOShenyang．1 inrats． ABSTRACT：OBJECTIVETo characteristicsofPAC．1after and dose stud3，thepharmacokinetic single multiple ratswere or dose METHODSTwo of administrateddose of60 regiments single multiple mg·kg—PAC．1．respectively．Theplasma at and concentrationsofPAC．1differenttimeweredetermineda validatedHPLCmethod．The by developed were withDAS2．0softwareand SPSS】6．0statisticsofturarc。RESULTS111emain parametersacquired anal)，zedusing PAC-1wereas ofa doseof pharmacokinetieparameterssingle followed：Tmxwere(0．79士0．19)h (1．2士0．3)hand(1．4士0．5)h：AUCo．t were(4．6士2．6)mg。L-1．h“and(6．0士3．1)mg’L-i．h一．and maleratsandfemale dose (6．3士3．3)mg‘L-I．h～in rats．respectively．Inmultiplestudy,TⅢ。were(0．75士0．22)hand(0．62士0．14)h， 下I／2zwere(1．0士0．4)hand(1．6士0．6)h：AUCo．t maleratsandfemale AUC#were(5．9±2．9)mg’L-h“and(10．5士7．4)mg’L-i．h—inrats，respectively． and(11．8士8．5)mg。L-h～．and CONCLUSIONThestatisticanah，sisshowsthatthereisno themain sign